Sarcoplasmic reticular Ca2+ uptake and Ca2+ release activities, protein content and mRNA levels in control and MI animals with or without ENP and LOS treatments for 4 weeks starting at 3 weeks after induction of MI
Parameters
Control
MI
MI+ENP
MI+LOS
A. Ca2+ uptake activity (nmol/mg per 2 min)
110 ± 8.15
63.5 ± 4.8*
92 ± 6.3†
82 ± 4.8†
B. Ca2+ release activity (nmol/mg per 15 s)
8.25 ± 0.32
4.95 ± 0.43*
7.60 ± 0.37†
7.20 ± 0.24†
C. Protein content (% of control)
Ryanodine receptor
100
58.5 ± 1.5*
85.9 ± 3.1†
83.8 ± 2.2†
Ca2+-stimulated ATPase
100
50.5 ± 2.5*
78.2 ± 1.8†
67 ± 2.5†
Calsequestrin
100
105.2 ± 4.8
98.3 ± 4.7
96.9 ± 13.1
Phospholamban
100
69.1 ± 5.9*
86.6 ± 4.4†
80.8 ± 8.2†
D. mRNA levels (% of control)
Ryanodine receptor
100
64.8 ± 5.3*
84.75 ± 2.6†
86.8 ± 4.5†
Ca2+-stimulated ATPase
100
73.9 ± 4.1*
86.7 ± 5.3†
98.6 ± 6.4†
Calsequestrin
100
105.4 ± 1.6
97.9 ± 7.1
97.4 ± 4.6
Phospholamban
100
78.3 ± 3.7*
97.3 ± 5.7†
92.0 ± 6.5†
Values are mean ± SE of 7 animals in each group. Data are based on the analysis of the information in table 5 and figures 3 and 4 in our papers Shao et al. Am J Physiol Circ Physiol. 2005;288:H1674–82 [113] and Guo et al. Mol Cell Biochem. 2003;254:163–72 [118]. *P < 0.05 compared with control; †P < 0.05 compared with MI group
Declarations
Acknowledgments
The infrastructure support for this project was provided by the St. Boniface Hospital Research Foundation, Winnipeg, Canada. Thanks are also due to Ms. Andrea Opsima for typing this manuscript.
Author contributions
SKB searched the literature, analyzed the data and wrote the first draft; AKS analyzed the data and wrote the manuscript; NSD conceived, designed and edited the article. All authors have read and agreed to the published version of the manuscript.
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