Table Info

Table 1.

Cardiac performance, status of RAS and oxidative stress in control and MI animals with or without ENP and LOS treatments for 4 weeks starting at 3 weeks after induction of MI

Parameters	Control	MI	MI + ENP	MI + LOS
A. Hemodynamic parameters
LVEDP (mmHg)	4.0 ± 0.2	15.9 ± 1.3^*	7.5 ± 0.6^†	6.9 ± 0.5^†
LVSP (mmHg)	133 ± 4.9	128 ± 3.2	131 ± 3.8	127 ± 3.9
LV + dP/dt (mmHg/s)	9,208 ± 1075	4,806 ± 745^*	7,690 ± 680^†	7,544 ± 722^†
LV − dP/dt (mmHg/s)	8,788 ± 956	4,326 ± 590^*	7,248 ± 702^†	7,312 ± 690^†
B. RAS activity parameters
Plasma ANG II (fmol/mL)	8.3 ± 1.4	125 ± 6.9^*	34 ± 3.5^†	192 ± 9.9^†
Plasma ACE activity (nmol/min per mL)	51 ± 3.3	85 ± 7.1^*	32 ± 2.4^†	145 ± 7.1^†
LV ACE activity (nmol/min per mg protein)	0.45 ± 0.03	0.69 ± 0.04^*	0.23 ± 0.02^†	0.84 ± 0.05^†
C. Oxidative stress levels
LV MDA (nmol/mg tissue lipids)	5.9 ± 0.4	19.1 ± 0.8^*	12.7 ± 0.3^†	10.1 ± 0.4^†
LV conjugated dienes formation (nmol/mg tissue lipids)	33 ± 1.9	56 ± 4.9^*	41 ± 3.0^†	37 ± 3.3^†
LV GSH (μmol/g tissue)	82 ± 1.6	36 ± 4.1^*	74 ± 4.1^†	68 ± 3.7^†
LV GSSG (μmol/g tissue)	12.4 ± 0.8	25.2 ± 2.6^*	14.2 ± 1.4^†	15.3 ± 1.6^†

Values are mean ± standard error (SE) of 4–6 animals in each group. ENP: enalapril (10 mg/kg per day); LOS: losartan (20 mg/kg per day); MI: myocardial infarction; RAS: renin-angiotensin system; ACE: angiotensin-converting enzyme; LVEDP: LV end diastolic pressure; LVSP: LV systolic pressure; + dP/dt: maximum rate of pressure development; -dP/dt: maximum rate of pressure decay; MDA: malondialdehyde; GSH: reduced glutathione; GSSG: oxidized glutathione. Data are based on the analysis of the information in our papers Shao et al. Am J Physiol Heart Circ Physiol. 2005;288:H2637–46 [116]; and Shao et al. Am J Physiol Heart Circ Physiol. 2005;288:H1674–82 [113]. ^*P < 0.05 compared with control; ^†P < 0.05 compared with MI group

Declarations

Acknowledgments

The infrastructure support for this project was provided by the St. Boniface Hospital Research Foundation, Winnipeg, Canada. Thanks are also due to Ms. Andrea Opsima for typing this manuscript.

Author contributions

SKB searched the literature, analyzed the data and wrote the first draft; AKS analyzed the data and wrote the manuscript; NSD conceived, designed and edited the article. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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