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References
Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association.Circulation. 2021;143:e984–e1010. [DOI] [PubMed] [PMC]
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.Am J Physiol Heart Circ Physiol. 2018;315:H1569–88. [DOI] [PubMed] [PMC]
El Khoudary SR, Aggarwal B, Beckie TM, Hodis HN, Johnson AE, Langer RD, et al. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.Circulation. 2020;142:e506–32. [DOI] [PubMed]
Kwaifa IK, Bahari H, Yong YK, Noor SM. Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical Implications.Biomolecules. 2020;10:291. [DOI] [PubMed] [PMC]
Nilsson PM. Early Vascular Aging in Hypertension.Front Cardiovasc Med. 2020;7:6. [DOI] [PubMed] [PMC]
Christensen A, Pike CJ. Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease.Front Aging Neurosci. 2015;7:130. [DOI] [PubMed] [PMC]
Northey JM, Cherbuin N, Pumpa KL, Smee DJ, Rattray B. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis.Br J Sports Med. 2017;52:154–60. [DOI] [PubMed]
Mosconi L, Berti V, Dyke J, Schelbaum E, Jett S, Loughlin L, et al. Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.Sci Rep. 2021;11:10867. [DOI] [PubMed] [PMC]
Weber MT, Maki PM, McDermott MP. Cognition and mood in perimenopause: A systematic review and meta-analysis.J Steroid Biochem Mol Biol. 2014;142:90–8. [DOI] [PubMed] [PMC]
Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress.GeroScience. 2020;42:1699–714. [DOI] [PubMed] [PMC]
Cyr AR, Huckaby LV, Shiva SS, Zuckerbraun BS. Nitric Oxide and Endothelial Dysfunction.Crit Care Clin. 2020;36:307–21. [DOI] [PubMed] [PMC]
Böger RH. Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials.Vasc Med. 2005;10 Suppl 1:S19–25. [DOI] [PubMed]
Lacolley P, Regnault V, Nicoletti A, Li Z, Michel JB. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles.Cardiovasc Res. 2012;95:194–204. [DOI] [PubMed]
Laurent S, Boutouyrie P. Arterial Stiffness and Hypertension in the Elderly.Front Cardiovasc Med. 2020;7:544302. [DOI] [PubMed] [PMC]
Pase MP, Beiser A, Himali JJ, Tsao C, Satizabal CL, Vasan RS, et al. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.Stroke. 2016;47:2256–61. [DOI] [PubMed] [PMC]
Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension.Circ Res. 2019;124:1025–44. [DOI] [PubMed] [PMC]
Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications.Lancet Neurol. 2019;18:684–96. [DOI] [PubMed]
Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS. Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury.JAMA Neurol. 2019;76:81–94. [DOI] [PubMed] [PMC]
Miller VM, Duckles SP. Vascular Actions of Estrogens: Functional Implications.Pharmacol Rev. 2008;60:210–41. [DOI] [PubMed] [PMC]
Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory.Proc Natl Acad Sci. 2011;108:3017–22. [DOI] [PubMed] [PMC]
Stillman CM, Cohen J, Lehman ME, Erickson KI. Mediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis.Front Hum Neurosci. 2016;10:626. [DOI] [PubMed] [PMC]
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A Meta-Analysis of Cytokines in Major Depression.Biol Psychiatry. 2010;67:446–57. [DOI] [PubMed]
Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain.Nat Rev Neurosci. 2008;9:46–56. [DOI] [PubMed] [PMC]
Albert K, Pruessner J, Newhouse P. Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle.Psychoneuroendocrinology. 2015;59:14–24. [DOI] [PubMed] [PMC]
Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, et al. Sex differences in Alzheimer risk.Neurology. 2017;89:1382–90. [DOI] [PubMed] [PMC]
Bucciarelli V, Caterino AL, Bianco F, Caputi CG, Salerni S, Sciomer S, et al. Depression and cardiovascular disease: The deep blue sea of women’s heart.Trends Cardiovasc Med. 2020;30:170–6. [DOI] [PubMed]
Rome D, Sales A, Leeds R, Usseglio J, Cornelius T, Monk C, et al. A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment.Curr Atheroscler Rep. 2022;24:709–20. [DOI] [PubMed] [PMC]
Di Francescomarino S, Sciartilli A, Di Valerio V, Di Baldassarre A, Gallina S. The Effect of Physical Exercise on Endothelial Function.Sports Med. 2009;39:797–812. [DOI] [PubMed]
Meadows JL, Vaughan DE. Endothelial biology in the post-menopausal obese woman.Maturitas. 2011;69:120–5. [DOI] [PubMed] [PMC]
Piercy KL, Troiano RP, Ballard RM, Carlson SA, Fulton JE, Galuska DA, et al. The Physical Activity Guidelines for Americans.JAMA. 2018;320:2020–8. [DOI] [PubMed] [PMC]
Madamanchi NR, Vendrov A, Runge MS. Oxidative Stress and Vascular Disease.Arterioscler Thromb Vasc Biol. 2005;25:29–38. [DOI] [PubMed]
Iantorno M, Campia U, Di Daniele N, Nistico S, Forleo GB, Cardillo C, et al. Obesity, inflammation and endothelial dysfunction.J Biol Regul Homeost Agents. 2014;28:169–76. [PubMed]
Green DJ, Maiorana A, O’Driscoll G, Taylor R. Effect of exercise training on endothelium‐derived nitric oxide function in humans.J Physiol. 2004;561:1–25. [DOI] [PubMed] [PMC]
Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women.J Clin Endocrinol Metab. 2012;97:4692–700. [DOI] [PubMed] [PMC]
Bogdanis GC, Stavrinou P, Fatouros IG, Philippou A, Chatzinikolaou A, Draganidis D, et al. Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans.Food Chem Toxicol. 2013;61:171–7. [DOI] [PubMed]
Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise.J Appl Physiol. 2005;98:1154–62. [DOI] [PubMed]
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease.Nat Rev Immunol. 2011;11:85–97. [DOI] [PubMed] [PMC]
Gielen S, Schuler G, Adams V. Cardiovascular Effects of Exercise Training.Circulation. 2010;122:1221–38. [DOI] [PubMed]
Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K, et al. Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis.Circulation. 2004;109:220–6. [DOI] [PubMed]
Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle.Physiol Rev. 1992;72:369–417. [DOI] [PubMed]
You Q, Yu L, Li G, He H, Lv Y. Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis.Front Physiol. 2022;12:803102. [DOI] [PubMed] [PMC]
Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.J Psychiatr Res. 2015;60:56–64. [DOI] [PubMed] [PMC]
Heijnen S, Hommel B, Kibele A, Colzato LS. Neuromodulation of Aerobic Exercise—A Review.Front Psychol. 2016;6:1890. [DOI] [PubMed] [PMC]
Tsatsoulis A, Fountoulakis S. The Protective Role of Exercise on Stress System Dysregulation and Comorbidities.Ann N Y Acad Sci. 2006;1083:196–213. [DOI] [PubMed]
Barker AL, Talevski J, Morello RT, Brand CA, Rahmann AE, Urquhart DM. Effectiveness of Aquatic Exercise for Musculoskeletal Conditions: A Meta-Analysis.Arch Phys Med Rehabil. 2014;95:1776–86. [DOI] [PubMed]
Schuch FB, Vancampfort D, Firth J, Rosenbaum S, Ward PB, Silva ES, et al. Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies.Am J Psychiatry. 2018;175:631–48. [DOI] [PubMed]
Casey DP, Beck DT, Braith RW. Progressive Resistance Training Without Volume Increases Does Not Alter Arterial Stiffness and Aortic Wave Reflection.Exp Biol Med. 2016;232:1228–35. [DOI] [PubMed]
Zhang Y, Zhang YJ, Ye W, Korivi M. Low-to-Moderate-Intensity Resistance Exercise Effectively Improves Arterial Stiffness in Adults: Evidence From Systematic Review, Meta-Analysis, and Meta-Regression Analysis.Front Cardiovasc Med. 2021;8:738489. [DOI] [PubMed] [PMC]
Green DJ, Hopman MT, Padilla J, Laughlin MH, Thijssen DH. Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiol Rev. 2017;97:495–528. [DOI] [PubMed] [PMC]
Joyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs.Physiol Rev. 2015;95:549–601. [DOI] [PubMed] [PMC]
Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, et al. Exercise for depression.Cochrane Database Syst Rev. 2013;2013:CD004366. [DOI] [PubMed] [PMC]
DeVan AE, Anton MM, Cook JN, Neidre DB, Cortez-Cooper MY, Tanaka H. Acute effects of resistance exercise on arterial compliance.J Appl Physiol. 2005;98:2287–91. [DOI] [PubMed]
Sun W, Han Y, Gu S. Effects of five types of exercise on vascular function in postmenopausal women: a network meta-analysis and systematic review of 32 randomized controlled trials.PeerJ. 2024;12:e17621. [DOI] [PubMed] [PMC]
Ramadhana DR, Putra RP, Sibarani MA, Sulistiawati S, Sari DR, Rejeki PS, et al. Short-term multicomponent exercise training improves executive function in postmenopausal women.PLoS One. 2024;19:e0307812. [DOI] [PubMed] [PMC]
Elavsky S, McAuley E. Physical activity, symptoms, esteem, and life satisfaction during menopause.Maturitas. 2005;52:374–85. [DOI] [PubMed]
Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training.J Appl Physiol. 2007;103:1655–61. [DOI] [PubMed]
Khalafi M, Sakhaei MH, Kazeminasab F, Symonds ME, Rosenkranz SK. The impact of high-intensity interval training on vascular function in adults: A systematic review and meta-analysis.Front Cardiovasc Med. 2022;9:1046560. [DOI] [PubMed] [PMC]
Taha MM, Aneis YM, Hasanin ME, Felaya EE, Aldhahi MI, Abdeen HAA. Effect of high intensity interval training on arterial stiffness in obese hypertensive women: a randomized controlled trial.Eur Rev Med Pharmacol Sci. 2023;27:4069–79. [DOI] [PubMed]
Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, et al. Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise.Physiol Behav. 2016;155:224–30. [DOI] [PubMed]
Shepherd SO, Wilson OJ, Taylor AS, Thøgersen-Ntoumani C, Adlan AM, Wagenmakers AJ, et al. Low-Volume High-Intensity Interval Training in a Gym Setting Improves Cardio-Metabolic and Psychological Health.PLoS One. 2015;10:e0139056. [DOI] [PubMed] [PMC]
Patten RK, McIlvenna LC, Moreno-Asso A, Hiam D, Stepto NK, Rosenbaum S, et al. Efficacy of high-intensity interval training for improving mental health and health-related quality of life in women with polycystic ovary syndrome.Sci Rep. 2023;13:3025. [DOI] [PubMed] [PMC]
Verges S, Chacaroun S, Godin-Ribuot D, Baillieul S. Hypoxic Conditioning as a New Therapeutic Modality.Front Pediatr. 2015;3:58. [DOI] [PubMed] [PMC]
Nishiwaki M, Kawakami R, Saito K, Tamaki H, Takekura H, Ogita F. Vascular adaptations to hypobaric hypoxic training in postmenopausal women.J Physiol Sci. 2011;61:83–91. [DOI] [PubMed] [PMC]
Park W, Park HY, Kim SW. Effects of 12 Weeks of Combined Exercise Training in Normobaric Hypoxia on Arterial Stiffness, Inflammatory Biomarkers, and Red Blood Cell Hemorheological Function in Obese Older Women.Healthcare. 2024;12:1887. [DOI] [PubMed] [PMC]
Bayer U, Likar R, Pinter G, Stettner H, Demschar S, Trummer B, et al. Effects of intermittent hypoxia-hyperoxia on mobility and perceived health in geriatric patients performing a multimodal training intervention: a randomized controlled trial.BMC Geriatr. 2019;19:167. [DOI] [PubMed] [PMC]
Behrendt T, Bielitzki R, Behrens M, Glazachev OS, Schega L. Effects of Intermittent Hypoxia-Hyperoxia Exposure Prior to Aerobic Cycling Exercise on Physical and Cognitive Performance in Geriatric Patients—A Randomized Controlled Trial.Front Physiol. 2022;13:899096. [DOI] [PubMed] [PMC]
Merellano-Navarro E, Camacho-Cardenosa M, Costa GP, Wiggers E, Marcolino Putti G, Evandro Nogueira J, et al. Effects of Different Protocols of Moderate-Intensity Intermittent Hypoxic Training on Mental Health and Quality of Life in Brazilian Adults Recovered from COVID-19: The AEROBICOVID Double-Blind Randomized Controlled Study.Healthcare. 2023;11:3076. [DOI] [PubMed] [PMC]
Chroboczek M, Kujach S, Łuszczyk M, Soya H, Laskowski R. Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men.Int J Environ Res Public Health. 2023;20:3629. [DOI] [PubMed] [PMC]
Burtscher J, Niedermeier M, Hüfner K, van den Burg E, Kopp M, Stoop R, et al. The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders.Neurosci Biobehav Rev. 2022;138:104718. [DOI] [PubMed]
Ramírez-delaCruz M, Bravo-Sánchez A, Sánchez-Infante J, Abián P, Abián-Vicén J. Effects of Acute Hypoxic Exposure in Simulated Altitude in Healthy Adults on Cognitive Performance: A Systematic Review and Meta-Analysis.Biology. 2024;13:835. [DOI] [PubMed] [PMC]
Roach EB, Bleiberg J, Lathan CE, Wolpert L, Tsao JW, Roach RC. AltitudeOmics: Decreased reaction time after high altitude cognitive testing is a sensitive metric of hypoxic impairment.NeuroReport. 2014;25:814–8. [DOI] [PubMed] [PMC]
Iadecola C. The Pathobiology of Vascular Dementia.Neuron. 2013;80:844–66. [DOI] [PubMed] [PMC]
Khalafi M, Malandish A, Rosenkranz SK. The impact of exercise training on inflammatory markers in postmenopausal women: A systemic review and meta-analysis.Exp Gerontol. 2021;150:111398. [DOI] [PubMed]