YI and OA: Conceptualization, Methodology, Writing—original draft, Writing—review & editing, Data curation, Formal analysis. SAG, OS, and KJ: Writing—review & editing. MS and LS: Conceptualization, Methodology, Writing—review & editing. PT: Conceptualization, Methodology, Writing—review & editing, Data curation, Formal analysis, Supervision. All authors read and approved the submitted version.
Conflicts of interest
Patricia Tai, who is the Editorial Board Member and Guest Editor of Exploration of Medicine, and Omar Alqaisi, who is the Guest Editor of Exploration of Medicine, had no involvement in the decision-making or the review process of this manuscript. The other authors declare no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
All relevant data are contained within the manuscript, as no new data are generated, and all selected studies are in the references.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
References
Bennett MI, Rayment C, Hjermstad M, Aass N, Caraceni A, Kaasa S. Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review.Pain. 2012;153:359–65. [DOI] [PubMed]
Paice JA. Cancer pain management and the opioid crisis in America: How to preserve hard-earned gains in improving the quality of cancer pain management.Cancer. 2018;124:2491–7. [DOI] [PubMed]
van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J. Prevalence of pain in patients with cancer: a systematic review of the past 40 years.Ann Oncol. 2007;18:1437–49. [DOI] [PubMed]
WHO guideline on balanced national controlled medicines policies to ensure medical access and safety [Internet]. Geneva: World Health Organization; 2025. [PubMed]
Al-Ghabeesh SH, Bashayreh IH, Saifan AR, Rayan A, Alshraifeen AA. Barriers to Effective Pain Management in Cancer Patients From the Perspective of Patients and Family Caregivers: A Qualitative Study.Pain Manag Nurs. 2020;21:238–44. [DOI] [PubMed]
Caraceni A, Hanks G, Kaasa S, Bennett MI, Brunelli C, Cherny N, et al.; European Palliative Care Research Collaborative (EPCRC); European Association for Palliative Care (EAPC). Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.Lancet Oncol. 2012;13:e58–68. [DOI] [PubMed]
Mercadante S, Bruera E. Opioid switching in cancer pain: From the beginning to nowadays.Crit Rev Oncol Hematol. 2016;99:241–8. [DOI] [PubMed]
World Health Organization, 2019. WHO Model List of Essential Medicines: 21st List (2019) [Internet].Coherent Digital, LLC; [cited 2025 Dec 12]. Available from: https://coilink.org/20.500.12592/7h621b
Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, et al. Association between opioid prescribing patterns and opioid overdose-related deaths.JAMA. 2011;305:1315–21. [DOI] [PubMed]
Volkow ND, Blanco C. The changing opioid crisis: development, challenges and opportunities.Mol Psychiatry. 2021;26:218–33. [DOI] [PubMed] [PMC]
Yennurajalingam S, Edwards T, Arthur JA, Lu Z, Najera J, Nguyen K, et al. Predicting the risk for aberrant opioid use behavior in patients receiving outpatient supportive care consultation at a comprehensive cancer center.Cancer. 2018;124:3942–9. [DOI] [PubMed]
Ako T, Ørnskov MP, Lykke C, Sjøgren P, Kurita GP. Prevalence of opioid misuse in patients with cancer: a systematic review and meta-analysis.Br J Cancer. 2024;131:1014–20. [DOI] [PubMed] [PMC]
Schatz AA, Oliver TK, Swarm RA, Paice JA, Darbari DS, Dowell D, et al. Bridging the Gap Among Clinical Practice Guidelines for Pain Management in Cancer and Sickle Cell Disease.J Natl Compr Canc Netw. 2020;18:392–9. [DOI] [PubMed] [PMC]
Ganguly A, Michael M, Goschin S, Harris K, McFarland DC. Cancer Pain and Opioid Use Disorder.Oncology (Williston Park). 2022;36:535–41. [DOI] [PubMed]
Russo MM, Sundaramurthi T. An Overview of Cancer Pain: Epidemiology and Pathophysiology.Semin Oncol Nurs. 2019;35:223–8. [DOI] [PubMed]
Chino F, Kamal A, Chino J. Incidence of Opioid-Associated Deaths in Cancer Survivors in the United States, 2006-2016: A Population Study of the Opioid Epidemic.JAMA Oncol. 2020;6:1100–2. [DOI] [PubMed] [PMC]
Boland JW, Ziegler L, Boland EG, McDermid K, Bennett MI. Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? A systematic literature review.Pain. 2015;156:2152–63. [DOI] [PubMed]
Vallejo R, de Leon-Casasola O, Benyamin R. Opioid therapy and immunosuppression: a review.Am J Ther. 2004;11:354–65. [DOI] [PubMed]
Sacerdote P. Opioid-induced immunosuppression.Curr Opin Support Palliat Care. 2008;2:14–8. [DOI] [PubMed]
Del Fabbro E. Assessment and management of chemical coping in patients with cancer.J Clin Oncol. 2014;32:1734–8. [DOI] [PubMed]
Saifan AR, Bashayreh IH, Al-Ghabeesh SH, Batiha AM, Alrimawi I, Al-Saraireh M, et al. Exploring factors among healthcare professionals that inhibit effective pain management in cancer patients.Cent Eur J Nurs Midwifery. 2019;10:967–76. [DOI]
Al Omari D, Alhabahbeh A, Subih M, Aljabery A. Pain management in the older adult: The relationship between nurses’ knowledge, attitudes and nurses’ practice in Ireland and Jordan.Appl Nurs Res. 2021;57:151388. [DOI] [PubMed]
Bulls HW, Chu E, Goodin BR, Liebschutz JM, Wozniak A, Schenker Y, et al. Framework for opioid stigma in cancer pain.Pain. 2022;163:e182–9. [DOI] [PubMed] [PMC]
Pergolizzi JV Jr, Magnusson P, Christo PJ, LeQuang JA, Breve F, Mitchell K, et al. Opioid Therapy in Cancer Patients and Survivors at Risk of Addiction, Misuse or Complex Dependency.Front Pain Res (Lausanne). 2021;2:691720. [DOI] [PubMed] [PMC]
Preux C, Bertin M, Tarot A, Authier N, Pinol N, Brugnon D, et al. Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review.J Clin Med. 2022;11:1594. [DOI] [PubMed] [PMC]
Carmichael AN, Morgan L, Del Fabbro E. Identifying and assessing the risk of opioid abuse in patients with cancer: an integrative review.Subst Abuse Rehabil. 2016;7:71–9. [DOI] [PubMed] [PMC]
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States.JAMA Netw Open. 2020;3:e2013605. [DOI] [PubMed] [PMC]
Saraswathula A, Chen MM, Mudumbai SC, Whittemore AS, Divi V. Persistent Postoperative Opioid Use in Older Head and Neck Cancer Patients.Otolaryngol Head Neck Surg. 2019;160:380–7. [DOI] [PubMed]
Yoo SH, Kang J, Kim HJ, Lee SW, Hong M, Jung EH, et al. Opioid use and subsequent delirium risk in patients with advanced cancer in palliative care: a multicenter registry study.Sci Rep. 2024;14:6004. [DOI] [PubMed] [PMC]
Jones KF, Broglio K, Ho JJ, Rosa WE. Compassionate Care for People with Cancer and Opioid Use Disorder.Am J Nurs. 2023;123:56–61. [DOI] [PubMed] [PMC]
Yusufov M, Pirl WF, Greer JA, Mazzola E, Dalrymple KL, Tulsky JA, et al. Study protocol for a pilot randomised controlled trial of a virtually delivered behavioural intervention (ACTION) for adults with cancer at risk for opioid use disorder.BMJ Open. 2024;14:e096546. [DOI] [PubMed] [PMC]
Singh SA, Moreland RA, Fang W, Shaikh P, Perez JM, Morris AM, et al. Compassion Inequities and Opioid Use Disorder: A Matched Case-Control Analysis Examining Inpatient Management of Cancer-Related Pain for Patients With Opioid Use Disorder.J Pain Symptom Manage. 2021;62:e156–63. [DOI] [PubMed] [PMC]
Hamlish T, Pasquinelli M, Gastala N, Huber M, Manst D, Andersen K, et al. A team-based approach to effective management of pain and opioid use disorder in patients with cancer: Case report.Curr Probl Cancer Case Rep. 2022;8:100196. [DOI]
Kale SS, Tosto GD, Rush LJ, Kullgren J, Russell D, Fried M, et al. Creating a Palliative Care Clinic for Patients with Cancer Pain and Substance Use Disorder.J Pain Symptom Manage. 2024;68:e138–45. [DOI] [PubMed] [PMC]
Weiss L, Kelly L, Bhurjee I. Understanding the Partial Agonist: Treating Cancer Pain in Patients with a History of Opioid Use Disorder (OUD) on Buprenorphine (FR226C).J Pain Symptom Manage. 2023;65:e528–9. [DOI]
Dobson M, Blackhall L. Managing opioids in cancer patients at high risk for substance use disorders: experience from an outpatient palliative care clinic (RP311).J Pain Symptom Manage. 2022;63:1073. [DOI]
Ji X, Hu X, Brock KE, Mertens AC, Cummings JR, Effinger KE. Early Posttherapy Opioid Prescription, Potential Misuse, and Substance Use Disorder Among Pediatric Cancer Survivors.J Natl Cancer Inst. 2022;114:895–906. [DOI] [PubMed] [PMC]
Beauchemin M, Dorritie R, Hershman DL. Opioid use and misuse in children, adolescents, and young adults with cancer: a systematic review of the literature.Support Care Cancer. 2021;29:4521–7. [DOI] [PubMed] [PMC]
Cuthbert CA, Xu Y, Kong S, Boyne DJ, Hemmelgarn BR, Cheung WY. Patient-level factors associated with chronic opioid use in cancer: a population-based cohort study.Support Care Cancer. 2020;28:4201–9. [DOI] [PubMed]
Shah A, Hayes CJ, Martin BC. Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use - United States, 2006-2015.MMWR Morb Mortal Wkly Rep. 2017;66:265–9. [DOI] [PubMed] [PMC]