Exploration of Medicine

Table 8. Some examples of the different combination approaches.

Method	Components	Remarks	Reference(s)
Shock and kill	OKT3 + IL-2	Clinically not effective	[168]
	ART + vorinostat (LRA) + AGS-004 (DC vaccine)	NCT02707900 Safe but not effective	[169, 170]
	ART + vorinostat (LRA) + VRC07-523LS (bNab)	NCT03803605	[171]
	ART + vorinostat (LRA) + disulfiram	NCT03198559 Evidence of latency reversal, but not safe	[172]
	Venetoclax (pro-apoptotic) + anti-CD3 plus anti-CD28 T cell stimulation	Bcl-2 antagonist	[173]
	CRISPRa + gRNA-V	In vitro, an effective all-in-one approach	[174]
	Vorinostat + acitretin	RIG-I inducer Reactivates latent HIV and induces apoptosis	[175]
	LEDGINs + JQ1	Inhibits the HIV-1 integrase and LEDGF/p75 interaction	[167]
	YSE028 + JQ1	PKC activator + BET bromodomain inhibitor	[176]
Block and lock	dCA + ART	Tat inhibitor	[177]
	LEDGINs + ZL0580	BRD4 modulator	[167, 178]
	Triplitode + ART (Tenofovir + lamivudine + Lopinavir / ritonavir + raltegravir)	Immune modulator	A
	ZL0580 + ART	BRD4 modulator	[179]
Block and clear	LPA + Capivasertib	Akt inhibitor	[180]

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CRISPRa: CRISPR activated; RIG-I: retinoic acid-inducible gene I; dCA: didehydro-cortistatin A; LRA: latency reversing agent; Akt: protein kinase B; A: NCT02219672 (not published yet).

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WK: Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

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