Exploration of Medicine

Table 5. Summary of recently initiated clinical trials on HIV vaccination according to ClinTrials.gov.

Vaccine	Study	Procedure	Status
426c.Mod.Core-C4b	NCT06006546	Germline (GL)-targeting HIV-1 envelope (Env) protein -derived immunogens to activate naïve B cells that express the unmutated GL forms of VRC01-class bnAbs Adjuvant: 3M-052-AF + alum	Recruiting
VRC07-523LS + PGDM1400LS + ChAdOx1.tHIVconsv1, ChAdOx1.HIVconsv62 prime, MVA.tHIVconsv4 + A244d11gp120	NCT06484335	Determine safety and impact on viral load setpoint Adjuvant: ALFQ	RV630 ACHIEV Phase I Not yet recruiting
VRC07-523LS	NCT06484335	VRC07-523LS (bNab) + PGDM1400LS (bNab) + ChAdOx1.tHIVconsv1 + ChAdOx1.HIVconsv62 prime + MVA.tHIVconsv4 + A244d11gp120 Adjuvant: ALFQ	Phase I Not yet recruiting
CH505 TF chTrimer + 3M-052-AF	NCT06680479	Induce new HIV-1 Env B-cell neutralizing immune responses Adjuvant: alum	A5422 Phase 1 Recruiting
GRAdHIVNE1	NCT06617091	Gorilla-isolated (GRAd32) adenovirus vectored networked epitopes vaccine	IAVI C114 Phase 1 Not yet recruiting
A244 + B.63521	NCT05423418	A244 consists of the gp120 Env glycoprotein HIV-1 subtype CRF_01AE A244 derived from the CM244 CRF_01AE Adjuvant: ALFQ	RV575 Phase 1 Recruiting
IHV01 + A244 + AHFG ± ALFQ	NCT04658667	IHV01: full-length single chain (FLSC) gp120-CD4 chimera subunit HIV-1 vaccine, encoded by a synthetic gene, which contains a human codon-optimized HIV (BaL) gp120 sequence followed by human CD4D1D2, with a flexible 20-amino acid linker Adjuvant: aluminum phosphate Patients had previously received a late boost of AIDSVAX^®B/E ± ALVAC in RV306	RV546 Recruiting
Maraviroc + Dolutegravir + Dendritic Cell Vaccine + Auranofin + Sirtuin Histone deacetylase inhibitor	NCT06805656	Multi-interventional approaches	Not yet recruiting
426c.Mod.Core-C4b	NCT06613789	Adjuvant: 3M-052-AF + alum	HVTN316 Phase 1
Hiltonol: Poly-ICLC-adjuvanted CD40. HIVRI.Env (VRIPRO)	NCT06665646	Who previously participated in the HVTN706/MOSAICO study and remain without HIV	Phase 1 Not yet recruiting
426c.Mod.Core-C4b	NCT06006546	Germline (GL)-targeting HIV-1 Env protein-derived immunogens to activate naïve B cells that express the unmutated GL forms of VRC01-class broadly neutralizing antibodies (bnAbs) ATI for elicitation of VRC01-lineage antibodies adjuvant 3M-052-AF + alum	Recruiting
Ad4-Env150KN + VRC-HIVRGP096-00-VP (Trimer 4571) with alum Ad4-Env145NFL + VRC-HIVRGP096-00-VP (Trimer 4571) with alum	NCT03878121	Adenovirus serotype 4 (Ad4)-based HIV vaccines Nasal administration	Phase 1 Recruiting
Stabilized CH505 TF chTrimer	NCT06680479	Inducing new HIV-1 Env B-cell neutralizing immune responses admixed with 3M-052-AF + alum	A5422 Phase 1
UVAX-1107 ± UVAX-1197	NCT06905275	Glycan-trimmed HIV-1 nanoparticle vaccine (UVAX-1107), followed by homologous or wild-type HIV-1 nanoparticle vaccine (UVAX-1197) boost, each adjuvanted with 3M-052-AF + alum	Phase 1 Not yet recruiting
Trimer 4571	NCT04985760	To generate bNabs against HIV trimer 4571 adjuvant: alum	Active, not recruiting

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AHFG: aluminum hydroxide fluid gel; ATI: (antiretroviral) analytical treatment interruption; Alum: aluminum hydroxide; ALF: army liposome formulation; ALFQ: army liposome formulation mixed with the saponin QS-21(Quillaja saponaria-21) adjuvant.

Declarations

Author contributions

WK: Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

Conflicts of interest

The author declares that there are no conflicts of interest.

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