Exploration of Medicine

Table 4. Gene therapy studies.

Method	Drug	Reference(s)
Modified T cells	AGT103-T	NCT05529342, NCT05540964, NCT04561258
ZFN-modified T cells	SB-728-T or SB-728mR-T	NCT04201782, NCT01044654
Modified T cells	Vector VRX496	NCT00295477
Modified lymphocytes	Lymphocytes, Gemini study	NCT04799483
Modified CD4⁺ and CD8⁺ cells	CD4⁺ and CD8⁺ cells	NCT00001409
Modified CD34⁺ cells	CD34⁺ cells ± busulfan	NCT03517631
CD4 CAR + CCR5 ZFN T-cells	T cells	NCT03617198
Modified lymphocytes	Lymphocytes + NeoR gene	NCT00001353
Naked DNA with human IL-12 mutant as an immune adjuvant	GX-12	NCT00517569
Modified T cells	pHIV7-shI-TAR-CCR5RZ treated CD4 cells	NCT01153646
Modified stem cells HSPC	SB-728mR-HSPC after conditioning with busulfan	NCT02500849
Modified T cells	CD4-zeta gene-changed T cells and/or IL-2 (recombinant interleukin-2)	NCT01013415
CRISPR/Cas9 gene editing	EBT-101 in AAV9 vector	NCT05144386
Anti-HIV-1 ribozyme transduced cells	OZ1	NCT00074997, NCT01177059

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ZFN: zinc finger nuclease; AAV9: adenovirus-associated virus vector serotype 9; HSPC: hematopoietic stem cell transplantation.

Declarations

Author contributions

WK: Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

Conflicts of interest

The author declares that there are no conflicts of interest.

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