Exploration of Medicine

Table 1. FDA-approved HIV drugs.

Drug	Class	FDA approval	Brandname	Remarks
Zidovudine	NRTI	1987	Retrovir
Lamivudine	NRTI	1995	Epivir
Abacavir	NRTI	1998	Ziagen
Tenofovir disoproxil fumarate	NRTI	2001	Viread
Emtricitabine	NRTI	2003	Emtriva
Tenofovir alafenamide	NRTI	2016	Vemlidy
Nevirapine	NNRTI	1996	Viramune	Discontinued
Efavirenz	NNRTI	1998	Sustiva	Discontinued
Etravirine	NNRTI	2008	Intelence
Nevirapine extended release	NNRTI	2011	Viramune XR	Discontinued
Rilpivirine	NNRTI	2011	Edurant	Discontinued
Rilpivirine	NNRTI	2024	Edurant PED	Discontinued
Doravirine	NNRTI	2018	Pifeltro
Raltegravir	INSTI	2007	Isentress
Raltegravir	INSTI	2017	Isentress HD
Dolutegravir	INSTI	2013	Tivicay
Dolutegravir	INSTI	2020	Tivicay PD
Cabotegravir	INSTI	2021	Apretude	Injection bimonthly Tablet
Cabotegravir	INSTI	2021	Vocabria	Injection bimonthly Tablet
Ritonavir	PI	1996	Norvir
Atazanvir	PI	2003	Reyataz
Fosamprenavir	PI	2003	Lexiva	Discontinued
Tipranvir	PI	2005	Aptivus
Darunavir	PI	2006	Prezista
Enfuvirtide	FI	2003	Fuzeon	Discontinued
Maraviroc	CCR5	2007	Selzentry
Cobicistat	PE	2014	Tybost
Fostemsavir	AI	2020	Rukobia
Ibalizumab	PAI	2018	Trogarzo
Lenacapavir	CI	2022	Sunlenca	Prophylaxis injection, 2 per year
Lenacapavir	CI	2025	Yeztugo	Prophylaxis injection, 2 per year

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NRTI: nucleoside reverse transcriptase inhibitors; NNRTI: non-nucleoside reverse transcriptase inhibitors; INSTI: integrase strand transfer inhibitors; PI: protease inhibitors; FI: fusion inhibitors; CCR5: C-C chemokine receptor type 5; PE: pharmacokinetic enhancer; AI: attachment inhibitors: bind to the gp120 protein of the virus; PAI: post-attachment inhibitors (block CD4 receptors on immune cells); CI: capsid inhibitors.

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WK: Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

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The author declares that there are no conflicts of interest.

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