Exploration of Medicine

From: Membranous-like glomerulopathy with monoclonal immunoglobulin deposits in a patient with class V lupus nephritis: a case report and literature review

Table 1. Flow cytometry and SPEP and serum-free light chain data, and other markers.

Tests	Values
T-cell/NK-cell markers
CD2	Positive; subset
CD3	Positive; subset
CD4	Positive; subset
CD5	Positive; subset
CD7	Positive; subset
CD8	Positive; subset
CD56	Positive; small subset
B-cell markers
CD19	Positive; subset
CD20	Positive; subset
CD22	Positive; subset
Kappa/CD19+	Polyclonal
Lambda/CD19+	Polyclonal
Myeloid markers
CD117	Negative
CD14	Negative
Plasma cell markers
CD38+/cKappa	Negative
CD38+/cLambda	Negative
CD138	Negative
Kappa-lambda quat. flow with ratio
Kappa quat. free light chains	3.30–19.40 mg/L
Lambda quat. free light chains	5.71–26.30 mg/L
Kappa/lambda free light chain ratio	0.26–1.65
SPEP
T protein	7.2 g/dL
Albumin	3.8 g/dL
Alpha 1	0.3 g/dL
Alpha 2	0.8 g/dL
Beta	1.0 g/dL
Gamma	1.4 g/dL

Return to article view

SPEP: serum protein electrophoresis.

Declarations

Acknowledgments

The abstract section of this manuscript was presented in the form of an abstract at the Kidney Week 2023 and is included in the conference abstract collection (https://www.asn-online.org/education/kidneyweek/2023/program-abstract.aspx?controlId=3944740).

Author contributions

MA: Writing—original draft, Writing—review & editing, Conceptualization, Methodology, Investigation, Resources. SM: Writing—original draft, Writing—review & editing, Conceptualization, Methodology, Investigation, Resources, Project administration, Supervision. AM: Writing—original draft, Writing—review & editing, Data curation, Formal analysis, Visualization, Investigation, Resources, Validation. DB, EAN, and BK: Writing—original draft, Writing—review & editing, Investigation, Resources. SA: Writing—original draft, Writing—review & editing, Data curation, Investigation, Resources, Validation. AE: Writing—original draft, Writing—review & editing, Investigation, Resources, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The approval number IRB-2023-0457 at the PCCR, Houston, TX.

Consent to participate

The authors certify that they have obtained the appropriate patient consent forms.

Consent to publication

The patient has given her consent for her clinical information to be reported in the journal.

Availability of data and materials

The data of this case report that supports our results are available on request from the corresponding author, Sreedhar Mandayam.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

References

Kannan L. A Unique Case of Membranous Lupus Nephritis Identified After Pronase Digestion. Cureus. 2022;14:e29083. [DOI] [PubMed] [PMC]

Almaani S, Parikh SV. Membranous Lupus Nephritis: A Clinical Review. Adv Chronic Kidney Dis. 2019;26:393–403. [DOI] [PubMed]

Larsen CP, Boils CL, Cossey LN, Sharma SG, Walker PD. Clinicopathologic Features of Membranous-Like Glomerulopathy With Masked IgG Kappa Deposits. Kidney Int Rep. 2016;1:299–305. [DOI] [PubMed] [PMC]

Larsen CP, Ambuzs JM, Bonsib SM, Boils CL, Cossey LN, Messias NC, et al. Membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int. 2014;86:154–61. [DOI] [PubMed]

Barcia-Sixto L, Isenberg D. Systemic lupus erythematosus: causes and manifestations. Trend Urol Mens Heal. 2020;11:26–9. [DOI]

Nasr SH, Galgano SJ, Markowitz GS, Stokes MB, D’Agati VD. Immunofluorescence on pronase-digested paraffin sections: a valuable salvage technique for renal biopsies. Kidney Int. 2006;70:2148–51. [DOI] [PubMed]