Amputation, osteomyelitis and risk factors in 75 patients with DFS enrolled in the study
Total Amputations (major and minor)
Risk Factor
Amputation NO
Amputation YES
P value
CRP > 65mg/L
6
15
0.03
Osteomyelitis
3
18
0.001
Insulin therapy
5
16
0.015
Duration of diabetes (≥ 20 years)
9
13
0.055
HbA1c > 55 mmol/mol
4
17
0.165
Previous revascularization
6
15
0.089
Osteomyelitis
Risk Factor
Osteomyelitis NO
Osteomyelitis YES
P value
CRP > 65 mg/L
13
29
0.001
Total Amputations
24
18
0.001
White blood cells > 12 × 109/L
24
18
0.003
Insulin therapy
13
29
0.003
Declarations
Author contributions
MM and CC conceived and designed this study. MM, AC, PA and FG designed the statistical analysis and analyzed the data. MM, FG, CC, AC and LR interpreted the results. MM wrote the first draft of manuscript. MM, FG, CC and LR contributed to the writing of the manuscript. All authors have read and confirmed the data in the manuscript and they can take the responsibility for the integrity of the data and the accuracy of the data analysis, read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflict of interest.
Ethical approval
The study was approved by the local Ethics Committee (reference number 855/2019).
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent of publication
Not applicable.
Availability of data and materials
The raw data supporting the conclusions of this manuscript will be made available by the authors to any qualified researcher. The datasets generated and/or analyzed during the current study are not publicly available as they are held by AOU Modena Health Organization as an integral part of their statutory activity. Any request for access should be directly submitted to Principal Investigator/Author.
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