Main demographic, diseases and therapeutic characteristics, and diagnostic and surgical interventions in the study population with DFS
| Characteristics | Mean value ± SD |
|---|---|
| Sex Males (%) | 73.3 |
| Age (years) | 70.9 ± 10.35 |
| Age of onset of T2D (years) | 49.2 ± 15.5 |
| Duration of diabetes (years) | 19.2 ± 16.3 |
| BMI (Kg/m2) | 30.2 ± 7.6 |
| Systolic Blood Pressure (mmHg) | 143.7 ± 20.5 |
| Diastolic Blood Pressure (mmHg) | 75.5 ± 10.9 |
| Heart Rate (bpm) | 80.4 ± 14.4 |
| Glasgow Come Scale (0–15) | 14.9 ± 0.3 |
| Pain scale (NRS 0–10) | 2.6 ± 3.4 |
| Body Temperature (°C) | 36.5 ± 0.7 |
| Co-morbidity at admission | Frequency (%) |
| Heart failure | 17.8 |
| Soft tissue inflammation | 82.7 |
| Osteomyelitis | 56 |
| PAD | 76 |
| Retinopathy | 40.5 |
| CKD (no. of patients) | 48 |
| Stage IIIa (eGFR 59-45 mL/min) | 20 |
| Stage IIIb (eGFR 44-30 mL/min) | 12 |
| Stage IV (eGFR 29-15 mL/min) | 12 |
| Stage V (eGFR < 15 mL/min) | 4 |
| Ischemic Heart Disease | 50 |
| Atrial Fibrillation | 14.7 |
| Previous Stroke | 13.3 |
| Active cancer | 5.4 |
| Dementia | 4 |
| Hepatic Steatosis | 16 |
| COPD | 6.7 |
| Smokers | 12.3 |
| Therapy at admission | Frequency (%) |
| Anti-hypertensive | 74.7 |
| Oral antidiabetics | 56.8 |
| Insulin | 54.1 |
| Antiplatelet agents | 64.4 |
| Statins | 54.1 |
| Primary Endpoints | Frequency (%) |
| Lower limb amputation (total 21 patients) | 28.4% |
| Major: 4.1% | |
| Minor/Curative: 24.3% | |
| Mortality in Diabetic Foot Unit (no patient) | 0% |
| Secondary Endpoints | Mean value ± SD |
| In-hospital duration of antibiotic therapy (days) | 18 ± 9.8 |
| Total duration of antibiotic therapy (days) | 23.9 ± 15.9 |
| Time of hospital stay (days) | 18.4 ± 7.9 |
| Others | Frequency (%) |
| Percutaneous angioplasty | 41.3% |
| Transfer to Intensive Care Unit (total 4 patients) | 5.3% |
MM and CC conceived and designed this study. MM, AC, PA and FG designed the statistical analysis and analyzed the data. MM, FG, CC, AC and LR interpreted the results. MM wrote the first draft of manuscript. MM, FG, CC and LR contributed to the writing of the manuscript. All authors have read and confirmed the data in the manuscript and they can take the responsibility for the integrity of the data and the accuracy of the data analysis, read and approved the submitted version.
The authors declare that they have no conflict of interest.
The study was approved by the local Ethics Committee (reference number 855/2019).
Informed consent to participate in the study was obtained from all participants.
Not applicable.
The raw data supporting the conclusions of this manuscript will be made available by the authors to any qualified researcher. The datasets generated and/or analyzed during the current study are not publicly available as they are held by AOU Modena Health Organization as an integral part of their statutory activity. Any request for access should be directly submitted to Principal Investigator/Author.
Not applicable.
© The Author(s) 2021.