Exploration of Medicine

Table 2. Postexposure management of HCWs after occupational exposure according to the previous hepatitis B vaccination and response status

HCW status	Postexposure serological test		Postexposure prophylaxis		Postvaccination serological (anti-HBs) test
HCW status	Source patient HBsAg	HCW testing Anti-HBs	HBIG	HBV vaccine	Postvaccination serological (anti-HBs) test
Confirmed response after complete HBV vaccine series	No action needed
Confirmed nonresponder after two complete HBV vaccine series	Positive or unknown	Not indicated	HBIG × 2 separated by 1 month	Not indicated	No
	Negative	No action needed
Unknown response after complete HBV vaccine series	Positive or unknown	< 10 mIU/mL	HBIG × 1	Initiate revaccination	Yes
	Negative	< 10 mIU/mL	No	Initiate revaccination	Yes
	Any results	≥ 10 mIU/mL	No action needed
Unvaccinated or incompletely vaccinated	Positive or unknown	Not indicated	HBIG × 1	Complete vaccination	Yes
Unvaccinated or incompletely vaccinated	Negative	Not indicated	No	Complete vaccination	Yes

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HCW: healthcare worker; HBsAg: hepatitis B surface antigen; anti-HBs: hepatitis B surface antibody; HBIG: hepatitis B immunoglobulin; HBV: hepatitis B virus

Declarations

Author contributions

HR and AT: Data curation, Writing—original draft, Writing—review & editing. ME: Supervision, Data curation, Writing—original draft. AGR: Data curation, Writing—original draft. MEK: Conceptualization, Data curation, Writing—original draft. All authors read and approved the submitted version.

Conflict of interest

The authors declare that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

All datasets generated or analyzed in the reviewed literature are included in the cited studies and referenced accordingly.

Funding

Not applicable.

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