The effects of targeting NLRP3 during wound healing

ChemicalEffect on NLRP3OutcomeReference
GenisteinIncreasedDelayed healing[136]
ZolIncreasedDelayed healing[137]
MetforminDecreasedFaster wound healing[138]
PaeoniflorinDecreasedPromoted healing[139, 140]
CalcitriolDecreasedPromoted healing[141]
Sanguisorba officinalisDecreasedPromoted healing[110]
MF-094DecreasedAccelerated healing[108]
Glyburide/GlibenclamideDecreasedImproved or delayed wound healing depending on time of administration[97]
MFG-E8DecreasedAccelerated healing[142]
FenofibrateDecreasedAccelerated healing[143]
N-AcetylcysteineDecreasedImproved healing[144]
MCC950InhibitedImproved healing or no effect[109, 145]
MelatoninInhibitedIncreased keratinocyte proliferation[146]
3,4-Methylenedioxy-β-nitrostyreneInhibitedImproved healing[129]
Bletilla striata polysaccharideInhibitedAccelerated healing[147]
Lactobacillus plantarumInhibitedImproved healing[111, 112]
Bay 11-7082InhibitedImproved healing[144]

Adapted from [118], CC BY. NLRP: nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein