Description of the qualitative characteristics and conclusive statements of innovative technologies for identifying oral potentially malignant disorders
| Type of study | Authors and journal | Intervention | Outcome measures and summary | Quality assessment score | Research setting |
|---|---|---|---|---|---|
| Review | Tatehara et al. [32], Cancers | Non-invasive diagnostic system based on light | In order to objectively distinguish between high-risk and low-risk OPMDs, it has been demonstrated that the 5-aminolevulinic acid-photodynamic diagnostic (ALA-PDD system) in conjunction with basic imaging processing has a greater sensitivity and specificity for detecting high-risk dysplasia and malignancy. | 7 | Department of Oral Medicine and Stomatology |
| Original Research | Kujan et al. [33], Journal of Oral Science | Oral brush | According to the study’s findings, oral liquid-based cytology with the Orcellex brush may hold great promise for the early diagnosis of precancerous and cancerous oral tissues. | 9 | University Dental Hospital of Manchester, United Kingdom; St Mary’s Hospital, Manchester, United Kingdom |
| Review | Abdul [34], Cureus | Advanced diagnostic aids | The most cutting-edge, forward-thinking diagnostic clinical approaches for advanced oral diagnostics include a multispectral digital microscope, time-resolved, laser-induced fluorescence spectroscopy, spectroscopy of diffuse reflectance, terahertz imaging, hyperspectral imaging, confocal laser endomicroscopy, quantum dots and nanoparticles, bionic sensor, and diagnostic molecular pathology. | 7 | Department of Oral Maxillofacial Surgery (OMFS) and Diagnostic Sciences at the College of Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia |
| Review | Cui et al. [38], Science and Technology of Advanced Materials | Advanced materials and technologies | In this review, the comparison of new and old materials and methodically outlined application techniques in advanced materials and technologies for oral disorders were explained based on the diseases’ etiology. | 7 | Science and Technology Innovation Center, Guangzhou University of Chinese Medicine |
| Systematical Review and Meta-Analysis | Kim et al. [39], Cancers (Basel) | Artificial intelligence (AI) | AI-powered automated lesion identification of malignant lesions in the mouth would be a quick, non-invasive diagnostic technique that might yield instantaneous results on the diagnostic work-up of oral cancer. | 8 | College of Medicine at the Catholic University of Korea |
| Original Research | Liu et al. [42], Oral Oncology | Convolutional neural networks | According to the study’s findings, it is possible to detect premalignant or precancerous oral lesions with computer-assisted detection, setting the stage for potential therapeutic application. | 10 | Rutgers, The State University of New Jersey; Department of Pathology, University of Pittsburgh School of Dental Medicine |
| Original Research | Gattuso et al. [43], Noncoding RNA | Liquid biopsy and circulating biomarkers | This study described the most promising biomarkers and the existing procedures to give an updated overview of the possible use of liquid biopsy as an additional tool for the management of oral lesions. | 9 | Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy |
| Original Research | Malone et al. [44], Cancers (Basel) | In vivo endoscopic optical coherence tomography | The study’s findings indicated that the stratification biomarkers show subsurface alterations, which may be useful in the future for determining therapy margins or choosing biopsy sites. | 9 | Department of Integrative Oncology, British Columbia Cancer Research Institute, Vancouver, BC, Canada |
| Original Research | Rebaudi et al. [45], Front Immunol | Non-invasive cyto-salivary sampling and rapid-highly sensitive ELISA immunoassay | According to the study’s findings, a non-invasive rapid phenotyping technique could be helpful as a screening tool for phenotyping oral lesions and support clinical practice by providing precise indications on the lesion’s characteristics. It could also be used to help patients with OSCC receive new anti-tumor treatments like immunotherapy. | 9 | University of Genova, Genova, Italy |
| Original Research | Saputra et al. [46], International Journal of Medical Science and Clinical Research Studies | VELScope | VELScope has an 83% 5-year survival rate, which contributes to a decrease in oral cancer mortality. Although it has limitations, further technological advancements may increase its precision, making it an essential instrument for precise early diagnosis and a reduction in the death rate from oral cancer. | 9 | Bachelor of Dental Surgery, Faculty of Dentistry, Universitas Jember |
OSCC: oral squamous cell carcinoma; OPMDs: oral potentially malignant disorders
