COVID-19 outcomes in cancer patients: impact of cancer type and treatment
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Overall COVID-19 outcomes in cancer patients
- Cancer patients face higher COVID-19 mortality, with outcomes varying by cancer type and treatment.- Studies report on both overall and short-term mortality rates.
Hematologic malignancies:- Worse COVID-19 outcomes, with a 33% mortality rate in a European study.Solid tumors:- High risk in lung, gastrointestinal, and CNS cancers, with lung cancer patients being particularly vulnerable.
Chemotherapy & chemoimmunotherapy:- Increased risk of severe outcomes due to immunosuppression.Immunotherapy, targeted, & endocrine therapies:- Endocrine therapies linked to fewer complications.
Chemotherapy:- Conflicting data on risk; a UK study found no increased risk, while others reported higher mortality, especially in hematologic cancers.Endocrine & other therapies:- Endocrine therapies are linked to fewer complications.
COVID-19 outcomes in cancer patients: research directions
Preventative therapeutics:- Development of agents to counter SARS-CoV-2’s oncogenic effects.Cancer surveillance:- Trials needed to assess long-term cancer risks in COVID-19 survivors.Omics approaches:- Genomic and proteomic research essential for understanding long-term oncogenic effects.
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