Table Info

Table 1.

Genetic variants identified and implicated in lung cancer [6]

Susceptibility loci	Tagging SNPs	Genes	References
3q28	rs4488809	TP63	[17–19]
5p15.33	rs402710 rs2736100 rs401681	intron 1 of TERT CLPTM1L	[20–23]
6p21.33	rs4324798 rs3117582	APOM, BAG6	[20, 21, 24]
8q21	rs2741354		[25]
9p21	rs1333040	CDKN2B-AS1	[26]
10q25.2	rs7086803	VTI1A	[27]
12p13.33	rs6489769	RAD52	[27]
12q23.1	rs12296850		[28]
13q31.3	rs2352028	GPC5	[29]
15q25.1	rs1051730 rs8034191 rs16969968 rs12914385	CHRNA3, CHRNA5, and CHRNB4	[20, 30, 31]
17q24.3	Rs7216064	BPTF	[32]
18p11.22	rs11080466 rs11663246	PIEZO2	[33]
22q12.2	rs17728461 rs36600	HORMAD2 LOC105372988	[17]
SNP: single nucleotide polymorphism

TP63: tumor protein 63; TERT: telomerase reverse transcriptase; CLPTM1L: cleft lip and palate transmembrane1-like; APOM: Apolipoprotein M; BAG6: Bcl-2-associated athanogen-6; CDKN2B-AS1: cyclin dependent kinase inhibitor 2B antisense RNA 1; VTI1A: Vps10p-tail-interactor-1a; RAD52: RAD52 homolog, DNA repair protein; GPC5: glypican-5; CHRNA3: cholinergic receptor nicotinic alpha 3 subunit; CHRNA5: cholinergic receptor nicotinic alpha 5 subunit; CHRNB4: cholinergic receptor nicotinic beta 4 subunit; BPTF: bromodomain PHD finger transcription factor; PIEZO2: piezo type mechanosensitive ion channel component 2; HORMAD2: hormonal regulators of muscle and metabolism in aging domain containing 2; LOC105372988: uncharacterized LOC105372988 [Homo sapiens (human)] gene type noncoding RNA. Blank space: not mentioned. References in the table refer to the ones in the original article [6] from which the table was reproduced

Note. Reprinted with permission from “Risk factors for lung cancer worldwide” by Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P. Eur Respir J. 2016;48:889–902 (https://erj.ersjournals.com/content/48/3/889). © ERS 2016.

Declarations

Author contributions

HA: Conceptualization, Project administration, Writing—original draft, Writing—review & editing. RF: Conceptualization, Writing—original draft, Writing—review & editing. MB: Writing—original draft, Writing—review & editing. All authors have read and accepted the published version of the manuscript.

Conflicts of interest

The authors declare they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

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