Genes discriminating between SCC and ADC

Gene Function Upregulation (SCC/ADC) Reference
DSC3 Ca2+-dependent glycoprotein involved in cell adherence SCC [22]
VSNL1 Neuronal Ca2+ sensor protein; tumour suppressor gene SCC [33, 34]
IRF6 Transcription factor SCC [35]
DST Cell adhesion SCC [36]
CLCA2 Cell adhesion; tumour suppressor SCC [37]
PIGX Tumour suppressor SCC -
DSG3 Cell adhesion SCC [3840]
LPCAT1 Cancer progression and metastasis ADC [41, 42]
SLC6A10 Neurotransmitter transporter; *pseudogene of SLC6A8 ADC [43]
CGN Tight junction ADC [21]

-: blank cell; Ca2+: calcium ion; *: pseudogene of its parent gene SLC6A8