Table Info

Table 1.

Genomics based platforms for drug repurposing

No.	Tools	Description
1	National Center for Biotechnology Information Gene Expression Omnibus	Provides microarray, NGS, and other functional genomic data.
2	Connectivity map	Resource for genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules to identify connections between drugs, genes, and diseases.
3	Gene2Drug	Integrates drug-gene expression signatures and information from pathway databases.
4	DeSigN	Predicts drug efficacy against cancer cell line using gene expression.
5	DSigDB	Resource that maps the drugs to their targets for GSEA.
6	ksRepo	Universal computational tools for drug repurposing.
7	DiseaseConnect	Resource to identify disease-disease relationships using gene expression data.
8	Cogena	Framework for co-expression analysis of gene expression signatures and GSEA of co-expressed genes.
9	SPIEDw	Web tool designed to facilitate fast and simple quantitative querying of publicly available gene expression data.
10	NFFinder	Uses transcriptomic data to find relationships between drugs, diseases, and a phenotype of interest.
11	PharmGKB	Pharmacogenomics resource for adjusting drug treatments.

No.: number; CMAP: connectivity map; NGS: next generation sequencing; DsigDB: drug signatures database; GSEA: gene set enrichment analysis; SPIEDw: searchable platform-independent expression database web version; PharmGKB: pharmacogenomics knowledgebase

Declarations

Acknowledgments

The authors are highly thankful to ISF College of Pharmacy, Moga for providing necessary facilities and encouragement.

Author contributions

PAC: Conceptualization, Writing—original draft. DS: Writing—original draft. AS: Writing—original draft. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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