Clinically approved treatments for neurological disorders induced by mitochondrial dysfunction

Drug nameActivityClinical trial number
EPI-743AntioxidantNCT01721733
KH176AntioxidantNCT02544217
RP103 (cysteamine bitartrate delayed release)Cystine-depleting agentNCT02023866
IdebenoneAntioxidantNCT00887562
RP103 (cysteamine bitartrate delayed release)Cystine-depleting agentNCT02473445
Medium chain triglyceridesShift heteroplasmyNCT01252979
L-arginineNO precursorNCT01603446
L-arginine (IV)NO precursorJMA-IIA00023
L-arginine (PO)NO precursorJMA-IIA00025
Arginine and citrullineNO precursorNCT01339494
TaurineTaurine modificationUMIN000011908
PyruvateNAD donorJMA-IIA00093
DCALowering lactate levelsNCT00068913

DCA: dichloroacetate; NO: nitric oxide