From:  Mechanisms and kinetics of drug release from lignin-based hydrogels: a review

 Properties of lignin and hydrogel for optimal network compatibility.

PropertyRole in network compatibilityCharacteristic of ligninCharacteristics of hydrogelImpact on composite performanceReferences
Hydroxyl groupDetermines the density of potential covalent crosslinking sites (e.g., with crosslinkers like epichlorohydrin, glutaraldehyde) or strong hydrogen bonding.450–900 mg KOH/g (for Kraft softwood lignin, representing 5–10 mmol/g of OH groups). Contains aliphatic and phenolic OH.Varies widely. polyvinyl alcohol (PVA): ~18 mmol/g OH groups. Polyacrylamide: requires functionalization; OH content is low natively.High OH content increases crosslinking density, enhancing tensile strength up to 400% and reducing swelling ratio.[2932]
Solubility & hydrophilicity (log P)Governs miscibility and dispersion of lignin within the hydrophilic hydrogel matrix. Prevents macroscopic phase separation.Log P ≈ 2.5–4.0 (hydrophobic). Poor water solubility; often requires chemical modification (e.g., sulfonation) for dispersion.Log P < 0 (hydrophilic). Designed to have high affinity for water, with equilibrium water content often greater than 90%.Good compatibility requires modifying lignin to improve hydrophilicity. Poor dispersion leads to brittle composites.[3336]
Glass transition temperature TgIndicates polymer chain mobility. A matched Tg between components suggests better molecular-level mixing and integration.Tg between ~90–180°C (for Kraft lignin). High Tg due to aromatic, rigid structure and hydrogen bonding.Tg between –20 to 120°C. Highly tunable. PVA: ~85°C. PAAm: ~165°C (theoretical). Often well below 0°C when swollen.A large mismatch can lead to phase separation. Lignin can act as a rigid filler, increasing the composite’s Tg and modulus.[3740]
Surface energy & interfacial tensionLow interfacial tension promotes spontaneous wetting and adhesion between lignin particles and the hydrogel polymer chains.~40–55 mJ/m2 (Dispersive component ~40 mJ/m2, Polar component variable).~30–45 mJ/m2 (e.g., PVA ~42 mJ/m2). High polar component due to hydrophilicity.Lower interfacial tension minimizes aggregation, leading to a more homogeneous composite and efficient stress transfer.[4143]
Particle size & morphologyDetermines the available surface area for interaction and defines the composite’s microstructure. Nanoscale size is critical.Nanoparticles (LNPs): 50–300 nm (via precipitation/ultrasonication). Micro-particles: 1–100 µm. Spherical or irregular.N/A (continuous polymer network). Pore size typically 1–100 nm in hydrogels.Lignin nanoparticles enable uniform distribution, act as multifunctional crosslinkers, and enhance mechanical properties.[23, 44, 45]
Rheological properties (G’, G”)Reflects the viscoelastic behavior and structural integrity of the pre-gel solution, indicating how well components mix.Aqueous dispersions can show G’ > G” at high concentrations (> 10 wt%), indicating gel-like behavior.Pre-gel solutions are typically viscous liquids with G” > G’. Crosslinking inverts this relationship.Incorporating lignin can increase the complex viscosity of the pre-gel solution, promoting better suspension and processability.[37, 46]