From:  Advancing infectious disease research through a chicken embryo model for developmental studies and antimicrobial screening of lipid nanoparticles

 Comparative advantages of LNPs over other nanocarriers.

FeatureLNPsLiposomesPolymeric NPsInorganic NPs
BiocompatibilityHighModerateModerateVariable
Drug LoadingHighModerateModerateVariable
StabilityHighModerateModerateOften high, may aggregate
Targeted deliveryEasily functionalizedPossible, less efficientPossiblePossible
Scalability & GMPEasyModerateModerateDifficult
Clinical translationValidated in mRNA vaccinesSome approved drugsLimitedMostly preclinical

LNPs: lipid nanoparticles; NP: nanoparticle.