Major findings supporting the involvement of CB2R in psychotic disorders

Animal studies
Genetic studies Genetic manipulation Animal specie Experimental test Behavioral changes References
CB2–/– Mouse, ICR OF ↑ sensibility to cocaine-induced hyperlocomotion [44]
SDIA short and long-term memory impairment [44, 71]
Pharmacological studies Drug Animal specie Experimental test Dosis Behavioral changes References
AM630 (CB2R antagonist) Mouse, C57BL/6J PPI 3 and 30 mg/kg ↑ alteration induced by MK-801 [42]
Mouse, ICR OF 2 mg/kg ↑ MK-801-induced hyperlocomotion [70]
JWH015 (agonista CB2R) Mouse, BALB/c PPI 1, 3 and 10 mg/kg ↓ alteration induced by MK-801 [67]
JWH133 (agonista CB2R) Mouse, ICR OF 20 mg/kg ↓ cocaine-induced hyperlocomotion [68]
Mouse, C57BL/6J OF 10, 20 and 30 mg/kg ↓ cocaine-induced hyperlocomotion [69]
Human studies
Parameter Population Results References
CB2R gene expression Caucasian ↓ reduction in PBMCs [57]
Polymorphism Population Results References
Japanese ↑ incidence [42]
rs2501432 Chinese (Han ethnic group) Allele T ↑ risk [58]
rs22229579 Allele T ↓ risk
rs6689530 rs34570472 Cnr2_ht1 Cnr2_ht2 Cnr2_ht3 Korean No effect [59]

OF: open field test; SDIA: step-down inhibitory avoidance; PBMCs: peripheral blood mononuclear cells