Table Info

Table 3.

Major findings supporting the involvement of CB₂R in psychotic disorders

Animal studies
Genetic studies	Genetic manipulation	Animal specie	Experimental test	Behavioral changes		References
	CB₂^–/–	Mouse, ICR	OF	↑ sensibility to cocaine-induced hyperlocomotion		[44]
			SDIA	short and long-term memory impairment		[44, 71]
			PPI	↑ PPI		[44, 71]
Pharmacological studies	Drug	Animal specie	Experimental test	Dosis	Behavioral changes	References
	AM630 (CB₂R antagonist)	Mouse, C57BL/6J	PPI	3 and 30 mg/kg	↑ alteration induced by MK-801	[42]
	AM630 (CB₂R antagonist)	Mouse, ICR	OF	2 mg/kg	↑ MK-801-induced hyperlocomotion	[70]
	JWH015 (agonista CB₂R)	Mouse, BALB/c	PPI	1, 3 and 10 mg/kg	↓ alteration induced by MK-801	[67]
	JWH133 (agonista CB₂R)	Mouse, ICR	OF	20 mg/kg	↓ cocaine-induced hyperlocomotion	[68]
	JWH133 (agonista CB₂R)	Mouse, C57BL/6J	OF	10, 20 and 30 mg/kg	↓ cocaine-induced hyperlocomotion	[69]

Human studies
Parameter	Population	Results	References
CB₂R gene expression	Caucasian	↓ reduction in PBMCs	[57]
Polymorphism	Population	Results	References
rs12744386 rs2501432	Japanese	↑ incidence	[42]
rs2501432	Chinese (Han ethnic group)	Allele T ↑ risk	[58]
rs22229579	Chinese (Han ethnic group)	Allele T ↓ risk	[58]
rs6689530 rs34570472 Cnr2_ht1 Cnr2_ht2 Cnr2_ht3	Korean	No effect	[59]

OF: open field test; SDIA: step-down inhibitory avoidance; PBMCs: peripheral blood mononuclear cells

Declarations

Acknowledgments

We thank all participants in this study. We greatly appreciated Biorender for helping to create figure 1.

Author contributions

MSGG and JM conceived the presented idea. MSGG took the lead in writing the manuscript. FN and AG wrote the manuscript in consultation with MSGG. All authors provided critical feedback and helped shape the research, analysis, and manuscript.

Conflicts of interest

The authors declare no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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