Major findings supporting the involvement of CB2R in depressive disorders

Animal studies
Genetic studiesGenetic manipulationAnimal specieExperimental testBehavioral changesReferences
CB2xPMouse, ICRTST↓ immobility time[39]
NSFT↓ latency time and ↑ food (g) consumption[39]
CMS↑ resistance
(↑ sucrose 1% consumption and ↓ immobility time in TST)
CB2–/–Mouse, ICRTST↑ immobility time[44]
DAT-Cnr2–/–Mouse, C57BL/6JTST, FST↑ immobility time[69]
Pharmacological studiesDrugAnimal specieExperimental testDosisBehavioral changesReferences
AM630 (CB2R antagonist)Mouse, ICRCMS1 mg/kg per 12 h (4 weeks)Antidepressive actions (↑ immobility time in TST and ↑ sucrose 1% consumption)[39]
Mouse, BALB/c
CMS3 mg/kg per 24 h (4 weeks)No effect[45]
Human studies
Q63R polymorphismJapanese↑ incidence[45]
CB2R expressionCaucasian↓ in DLPFC and amygdala[56]

TST: tail suspension test; NSFT: novelty suppressed feeding test; FST: forced swimming test; CMS: chronic mild stress