Exploration of Neuroprotective Therapy

Table 2. The detailed molecular docking information of CAP with hub proteins.

Gene symbol	Protein	Function^a	∆G^b (kcal/mol)	Residues
IL6	Interleukin-6	The protein is a potent inducer of the acute phase response.	–5.8	GLU87-LEU90-ASN91-LEU92 PRO93-LYS94-MET95-PHE102-PHE122-LEU193-ILE194-ARG196-SER197-PHE198-LYS199-GLU200-PHE201-LEU202-GLN203-SER204-ARG207
GSK3B	Glycogen synthase kinase-3 beta	Active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis.	–4.0	ARG6-THR7-THR8-SER9 PHE10-ALA11-GLU12-VAL17-GLN18-GLN19-PRO20-SER21-ALA22-PHE23-ASP49-SER66-PHE67-GLY68-LYS85-VAL87-LEU88-GLN89-ASP90-LYS91-ARG92-PHE93-LYS94-ASN95-ARG96-GLU97-LEU98-GLN99-ARG102-PHE115-TYR117-VAL126-PHE201-GLY202-ALA204
CASP3	Caspase 3	The protein plays a central role in the execution phase of cell apoptosis.	–6.5	MET61-THR62-SER63 HIS121-GLY122-GLU123-PHE128-CYS163-LEU168-TYR204-SER205-TRP206-ARG207-ASN208-SER209-TRP214-SER249-PHE250-SER251-PHE252-ASP253-PHE256
BCL2	Apoptosis regulator Bcl-2	An integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells.	–5.1	SER97 ARG98 SER99-ALA100-PRO101-PRO102-ASN103-LEU104-TRP105-ALA106-ALA107-GLN108-ARG109-TYR110-GLY111-ARG112-GLU113-ARG115-ARG116
ESR1	Estrogen receptor 1	An estrogen receptor and ligand-activated transcription factor.	–8.4	MET343-LEU345-LEU346-THR347-LEU349-ALA350-GLU353-TRP383-LEU384-LEU387-MET388-GLY390-LEU391-ARG394-LEU402-LEU403-PHE404-MET421-ILE424-PHE425-LEU428-GLY521-MET522-HIS524-LEU525-LEU540
SIRT1	Sirtuin 1	Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.	–8.7	GLY261-ALA262-GLY263-ASP272-PHE273-ARG274-SER275-TYR280-GLN294-PHE297-GLN345-ASN346-ILE347-HIS363-GLY364-ILE411-VAL412-PHE413-PHE414-GLY415-GLU416-LEU418-GLY440-SER441-SER442-LEU443-LYS444-VAL445-ARG446-PRO447-ASN465-ARG466-GLU467
NGF	Nerve growth factor	Protein involved in the regulation of growth and the differentiation of sympathetic and specific sensory neurons.	–6.8	LEU44-ALA47-LEU48-ARG50-ALA51-ALA54-PRO55-ALA56-ALA57-ALA58-ILE59-ALA60-ARG81-LEU82-ARG83-SER84-ASP151-ILE152-LYS153-THR206-PHE207-VAL208-LYS209-ASP214-GLN217-ALA219-TRP220-ARG221-PHE222
IGF1	Insulin-like growth factor 1	Protein is involved in mediating growth and development.	–6.4	LEU35-LEU37-CYS38-LEU39-THR41-PHE42 SER45-LEU53-GLU57-LEU58-ASP60-ALA61-PHE64-VAL65-CYS95-CYS96-ARG98-SER99-CYS100-ASP101-LEU102-LEU105
HMOX1	Heme oxygenase 1	An enzyme in heme catabolism.	–7.1	LEU17-LYS18-GLU19-THR21-LYS22-HIS25-THR26-ALA28-GLU29-MET34-GLN38-VAL50-LEU54-TYR58-TYR114-TYR134-THR135-ARG136-TYR137-LEU138-GLY139-ASP140-SER142-GLY143-GLY144-VAL146-LEU147-ILE150-PHE166-PHE167-ARG183-PHE207-ASN210-PHE214-LEU272-LEU274-SER275-PHE276

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a: Information is taken from the National Library of Medicine (NIH) page; b: the outcomes represent the values with a high binding activity.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1004132_sup_1.pdf.

Declarations

Acknowledgments

Luis Antonio Ramirez-Contreras (CVU: 1319432), Luis Alfonso Hernández-Villaseñor (CVU: 629990), and Salvador Hernández-Estrada (CVU: 1319414) gratefully acknowledge the financial support for the scholarship from SECIHTI-México for Doctoral studies in the Biociencias program from the Centro Universitario de Los Altos (CUALTOS) of the University of Guadalajara. Andrés Frausto de Alba (CVU: 1272002) gratefully acknowledges the financial support for the scholarship from SECIHTI-México for Doctoral studies in the Ciencia y Tecnología program from the Centro Universitario de Los Lagos (CULAGOS) of the University of Guadalajara. Thanks to the Instituto de Investigación en Ciencias Médicas from CUALTOS for the infrastructure support, the Molecular Modelling and Materials area from Centro Universitario de Los Lagos (CULAGOS), and the University of Guadalajara’s Data Analysis and Supercomputing Centre (CADS) for the computational and technical support provided through the Leo Atrox supercomputer.

Author contributions

LARC: Conceptualization, Methodology, Software, Formal analysis, Investigation, Data curation, Writing—original draft, Writing—review & editing, Visualization. LMAE: Conceptualization, Validation, Investigation, Resources, Writing—original draft, Writing—review & editing, Visualization, Supervision. SHE: Validation, Investigation, Writing—review & editing, Visualization. LAHV: Validation, Investigation, Writing—review & editing, Visualization. JMSJ: Validation, Writing—original draft, Writing—review & editing, Visualization, Supervision. LHH: Validation, Investigation, Resources, Visualization, Supervision. GCH: Validation, Investigation, Resources, Visualization, Supervision. AFdA: Methodology, Software, Validation, Formal analysis, Investigation, Data curation, Writing—original draft, Writing—review & editing, Visualization. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Data related to capsaicin targets, Parkinson’s disease targets, and Alzheimer’s disease targets, among other data, supporting the findings of this study are available from the corresponding author upon reasonable request.

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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