Exploration of Medicine

From: Signaling pathways and targets of natural products in psoriasis treatment

Table 3. The effects of herbal formulas on psoriasis

Formula	Composition Plant		Extract method	*In vitro*	*In vivo*	Signaling pathway(s)	Target(s)	Reference
Formula	Plant	Used part	Extract method	*In vitro*	*In vivo*	Signaling pathway(s)	Target(s)	Reference
Bai Xuan Xia Ta Re Pian	Euphorbiae humifusae L.	Aerial part	-	-	Mice	Th17 cell differentiation	IL-17, IL-23	[40]
	Terminalia chebula Retz.	Young fruit Ripe fruit
	Terminalia bellirica Roxb.	Fruit
	Aloe vera	Leaf
	Convolvulus scammonia	Resin
Dang Gui Liu Huang Tang	Angelica acutiloba Kitag.	Root	EtOH	HaCaT	Mice	MAPK; STAT3	IL-22, CXCL10, K16, K17, Ki67	[76]
	Rehmannia glutinosa Libosch.
	Scutellaria baicalensis Georgi.
	Astragalus membranaceus Bunge.
	Coptis chinensis Franch.
	Phellodendron amurense Rupr.	Peel
Gold lotion	Citrus sinensis	Peel	EtOH	DCs	Mice	Th17 cell differentiation	IL-17, IL-22	[39]
	Citrus hassaku
	Citrus limon
	Citrus natsudaidai
	Citrus miyauchi Iyo
	Citrus unshiu
PAMs	Carthamus tinctorius	-	EtOH	HaCaT	Mice	NF-κB	IL-8, TNF-α, ICAM-1, IL-23	[54]
	Lithospermum erythrorhizon
	Solanum indicum
	Cymbopogon distans
PSORI-CM01	Curcuma zedoaria	Rhizome	-	HaCaT	Mice	NF-κB; Th17 cell differentiation	IL-6, IL-8, CXCL10, CCL20	[100]
	Sarcandra glabra	Aerial part
	Smilax glabra Roxb.	Rhizome
	Prunus mume	Fruit
	Arnebia euchroma (Royle) Johnst.	Root
	Paeonia lactiflora
	Glycyrrhiza uralensis
PSORI-CM02	Smilax glabra Roxb.	Rhizome	Water	HaCaT	Mice	PI3K/Akt/mTOR	Beclin1, Atg 7, Atg 16L1, Atg 3	[78]
	Sarcandra glabra (Thunb.) Nakai	Leaf		HaCaT		PI3K/Akt/mTOR	Beclin1, Atg 7, Atg 16L1, Atg 3	[78]
	Paeonia lactiflora Pall	Root		RAW264.7		STAT1; STAT6	TNF-α, iNOS, IL-1β	[77]
	Curcuma phaeocaulis Val.	Root
	Prunus mume Sieb. et Zucc.	Fruit
Psoriasis 1	Smilacis glabrae	Rhizome	-	HaCaT	Rat	NF-κB; STAT	TNF-α, IFN-γ, IL-22, IL-17, IL-1β, IL-4	[102]
	Folium isatidis	Leaf
	Isatis tinctoria L.	Root
	Angelica sinensis	Root
	Hedyotis diffusa	Aerial part
	Ligusticum striatum	Rhizome
	Plantago major	Leaf		PBMCs	-	STAT4	IL-17, IL-23, TNF-α, IFN-γ, IL-2, IL-6, IL-4, TGF-β	[101]
	Kochia scoparia	Fruit
	Lobelia chinensis	Aerial part
	Alisma orientale	Rhizome
	Dictamnus dasycarpus Turcz.	Cortex
	Glycyrrhiza uralensis	Root

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Atg7: autophagy related 7; PAMs: plant antimicrobial solutions; TGF-β: transforming growth factor-beta; -: not applicable

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