Table Info

Table 1.

The effects of extracts on psoriasis

Plant	Used part	Extract method	*In vitro*	*In vivo*	Signaling pathway(s)	Target(s)	Reference
Actinidia arguta	Fruit	Water	HaCaT	Mice	NF-κB; STAT	IL-17	[87]
Alpinia galanga	Rhizome	EtOH	HaCaT	-	NF-κB	IL-8, CD40, CSF1	[45]
Annona squamosa	Leaf
Curcuma longa	Rhizome
Antrodia cinnamomea	Fruit	EtOH	T cells	Mice	Th17 cell differentiation	IL-17A, IL-21, IL-22, TNF-α	[30]
Artemisia capillaris	Whole part	EtOH	HaCaT	Mice	Apoptosis	Ki67, ICAM-1	[103]
Astragalus sinicus L.	Root	MeOH/CH₂Cl₂	HaCaT; T cells	Mice	NF-κB; JAK/STAT; PI3K/Akt	IL-17, IL-22, IL-10	[86]
Baphicacanthus cusia (Ness) Bremek	Aerial part	-	aHK; HMEC-1; Jurkat T; U937	Mice	Th17 cell differentiation	S100A9, IL-6, IL-8, CCL20	[31]
Copaifera langsdorffii Desf.	Oleoresin	-	THP-1	-	NF-κB	IL-1β, IL-6, TNF-α	[46]
Datura metel L.	Flower	EtOH	-	Mice	TLR7/8–MyD88– NF-κB–NLRP3 inflammasome	IL-1β, IL-2, IL-6, IL-10, IL-12, IL-17, IL-22, IL-23, TNF-α, MCP-1	[89]
Dictamnus dasycarpus Turcz.	Root bark	MeOH	-	Mice	STAT3; Th17 cell differentiation	IL-17, IFN-γ	[72]
Euphorbia kansui	Root	MeOH	T cells	Mice	Th17 cell differentiation	IL-17, IL-22, IL-23, IL-12	[32]
Gynura pseudochina (L.)	Leaf	EtOH	HaCaT	-	NF-κB	IL-8	[44]
Illicium verum Hook. f.	Fruit	EtOH	HaCaT	-	JAK/STAT	ICAM-1	[60]
Lavandula angustifolia	Essential oil	-	-	Mice	Th17 cell differentiation	IL-17, IL-22, TNF-α, IL-1β	[28]
Picea mariana	Cortex	Water	Keratinocytes	-	NF-κB	ICAM-1, IL-6, IL-8, NO	[47]
Pinus massoniana	Rosin	Water	Splenocytes	Mice	Th17 cell differentiation	IL-17, IL-22, IL-23, TNF-α, K17, PCNA	[27]
Rehmannia glutinosa	Root	EtOH	-	Mice	JAK/STAT	TNF-α, IL-6, IL-23, IL-17	[61]
Salvia miltiorrhiza	Root	-	HaCaT	Mice	Hippo	Caspase-3, Bcl-2, BAX, p53, p21	[105]
Sinapis Alba Linn	Seed	-	-	Mice	NLRP3 inflammasome	IL-1β, IL-18, caspase-1, ASC	[88]
Sinapis Alba Linn	Seed	-	Splenocytes		NF-κB	IL-17, IL-22, IFN-α, iNOS	[90]
Solanum xanthocarpum	Stem	EtOH	-	Mice	Th17 cell differentiation	TNF-α, IL-1β, IL-6, IL-17	[29]
Tripterygium wilfordii Hook. f.	-	-	T cells	Mice	STAT3	IL-17, IL-22	[62]
Vitis vinifera L.	Leaf	Water	THP-1; HEKa	Mice	AIM2 inflammasome	IL-17, IL-1β, IL-18, caspase-1, ASC	[104]
Withania somnifera	Seed	-	A431; THP-1; RAW264.7	Mice	NF-κB	TNF-α, IL-6	[48]

aHK: adult human keratinocyte; AIM2: absent in melanoma 2; ASC: apoptosis-associated speck-like protein containing a caspase recruitment domain; BAX: B cell lymphoma-2 associated X; Bcl-2: B cell lymphoma-2; CCL20: C-C motif chemokine ligand 20; CH₂Cl₂: dichloromethane; CSF1: colony-stimulating factor 1; EtOH: ethanol; HaCaT: human immortalized keratinocytes; HEKa: human epidermal keratinocytes, adult; HMEC-1: human dermal microvascular endothelial cell line; ICAM-1: intercellular adhesion molecule-1; iNOS: inducible nitric oxide synthase; JAK: Janus kinase; MCP-1: monocyte chemotactic protein 1; MeOH: methanol; MyD88: myeloid differentiation primary response 88; NF-κB: nuclear factor-kappa B; NLRP3: nucleotide-binding oligomerization domain-like receptor protein 3; NO: nitric oxide; PCNA: proliferating cell nuclear antigen; PI3K: phosphatidylinositol 3-kinase; STAT: signal transducer and activator of transcription; THP-1: Tohoku hospital pediatrics-1; TLR: toll-like receptor; -: not applicable

Declarations

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

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Funding

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Copyright

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