Ang-(1-7) in animal models of stroke
| Type of stroke induced | Animal model | Main finding | References |
|---|---|---|---|
| Ischemic stroke | Endothelin1-induced middle cerebral artery occlusion (MCAO) | - Ang-(1-7) central administration reduced the brain infarct size and neurological alteration 72 h after the insult.- Beneficial actions of Ang-(1-7) were mediated by MasR. | Mecca et al., 2011 [109] |
| Permanent middle cerebral artery occlusion (pMCAO) | - Intracerebral infusion of Ang-(1-7) decreased infarct volume and improved neurological alteration after 24 h following the insult.- Ang-(1-7) had an antioxidant effect, inhibited NF-κB activity and decreased pro-inflammatory cytokines and COX-2 in the peri-infarct areas.- Beneficial actions of Ang-(1-7) were mediated by MasR. | Jiang et al., 2012 [93] | |
| - Intracerebral infusion of Ang-(1-7) for 4 weeks reduced infarct size and neurological alteration after pMCAO.- Ang-(1-7) increased cerebral capillary density via stimulation of endothelial cell proliferation and eNOS activation.- Beneficial effects of Ang-(1-7) were mediated by MasR. | Jiang et al., 2014 [126] | ||
| - Ang-(1-7) infusion exerted a direct neuroprotective action during l ischemic injury in the brain by reducing cell swelling and death. These effects were mediated by decreased NOX expression with the consequent reduction of ROS production.- The beneficial effect of Ang-(1-7)/MasR stimulation on cerebral ischemic injury showed a greater protective effect in older animals.- Neuroprotective effects of Ang-(1-7) were mediated by MasR. | Zheng et al., 2014 [128] | ||
| Hemorrhagic stroke | Stroke-prone SHRs (spSHRs) | - ICV Ang-(1-7) infusion into spSHRs fed a high-sodium (4%) diet for 6 weeks decreased the number of hemorrhages in the striatum, enhanced neurological status, reduced the striatal microglia and increased survival.- Ang-(1-7) effects were partly prevented by ICV infusion of the MasR blocker, A-779. | Regenhardt et al., 2014 [127] |
| Intracerebral hemorrhage | - ICV infusion of Ang-(1-7) enhanced neurological function compared with rats that received control solution. | Del Bigio et al., 1996 [129] |
COX-2: cyclooxygenase 2; eNOS: endothelial nitric oxide synthase; NOX: NADPH oxidase; ROS: Reactive oxygen species
