From:  Associations of polypharmacy with cognitive impairment and functional status among older adults

 Associations of polypharmacy with cognitive function and functional status.

OutcomeModelEffect size (95% CI)p-value
Cognitive impairment (≤ 23)CrudeOR 1.70 (1.40–2.05)< 0.001
Model 1OR 1.03 (0.83–1.26)0.811
Model 2OR 0.64 (0.51–0.81)< 0.001
K-ADL scoreCrudeB 0.47 (SE 0.05)< 0.001
Model 1B 0.36 (SE 0.05)< 0.001
Model 2B 0.14 (SE 0.05)0.007
K-IADL scoreCrudeB 1.53 (SE 0.11)< 0.001
Model 1B 1.15 (SE 0.11)< 0.001
Model 2B 0.43 (SE 0.12)< 0.001

Model 1: adjusted for sex, age, education, income, employment, alcohol, and exercise. Model 2: Model 1 + number of chronic diseases. OR: odds ratio; B: unstandardized regression coefficient; SE: standard error; CI: confidence interval; K-ADL: Korean Activities of Daily Living; K-IADL: Korean Instrumental Activities of Daily Living.