From:  Associations of polypharmacy with cognitive impairment and functional status among older adults

 Cognitive function and functional status according to polypharmacy status.

Variables0–4 drugs
(n = 9,355)
N (%)
≥ 5 drugs
(n = 462)
N (%)
p-value
Cognitive category< 0.001
0–17668 (7.1)43 (9.3)
18–232,215 (23.7)156 (33.8)
24–306,472 (69.2)263 (56.9)
Cognitive score26 (5)25 (6)< 0.001
K-ADL score7 (0)7 (1)< 0.001
K-IADL score10 (0)10 (3)< 0.001

*p-values were calculated using chi-square tests for categorical variables and the Mann-Whitney U test for continuous variables. Continuous variables are presented as median (interquartile range, IQR). All analyses applied sampling weights. Due to missing responses in the K-MMSE assessment, the total frequency for cognitive categories is lower than the group totals. K-ADL: Korean Activities of Daily Living; K-IADL: Korean Instrumental Activities of Daily Living; K-MMSE: Korean version of the Mini-Mental State Examination.