From:  Reduced versus standard dose craniospinal irradiation with chemotherapy to treat medulloblastoma

 Study survival percentages grouped by year.

Survival percentagesAuthorEFS ± SD (95% CI)PFS ± SD (95% CI)OS ± SD (95% CI)
3-year survival percentagesDufour et al., 2021 [16]NR78 (65–88)84 (72–92)
Okada et al., 2020 [22]NRSR: 90.5 ± 5.2
HR: 100
SR: 93.9 ± 4.2
HR: 100
Packer et al., 1994 [23]90 ± 490 ± 4NR
Rieken et al., 2011 [26]NRLPFS: 73
DPFS: 87
Overall: 84
Tian et al., 2020 [30]NRNRPF: 59.1
TB: 70
4-year survival percentagesAshley et al., 2012 [13]50 ± 6NR69 ± 5.5
5-year survival percentagesAllen et al., 2009 [12]NR43 ± 552 ± 5
Gajjar et al., 2006 [5]SR: 83 (73–93) (p = 0.046)
HR: 70 (55–85)
NRSR: 85 (75–94) (p = 0.04)
HR: 70 (54–84)
Jakacki et al., 2012 [18]NRRegimen A: 71 ± 11
Regimen B: 59 ± 10
Regimen A: 82 ± 9
Regimen B: 68 ± 10
Lannering et al., 2012 [19]Overall: 82 ± 2
STRT: 77 ± 4
HFRT: 78 ± 4
NRSTRT: 87 ± 3
HFRT: 85 ± 3
Lee et al., 2020 [20]71.1 ± 8NR73.2 ± 7.9
Massimino et al., 2012 [21]Overall: 48 ± 6
Patients ≤ 10 years: 38 ± 8
Patients > 10 years: 59 ± 8
NROverall: 56 ± 6
Patients ≤ 10 years: 41 ± 8
Patients > 10 years: 73 ± 8
Merchant et al., 2008 [8]83 ± 5.3NR94.7 ± 3.4
Michalski et al., 2021 [7]IFRT: 82.5 (77.2–87.8)
PFRT: 80.5 (75.2–85.8)
LDCSI: 71.4 (62.8–80) (p = 0.028)
SDCSI: 82.9 (75.6–90.2)
NRIFRT: 84.6 (79.7–89.5)
PFRT: 85.2 (80.5–89.9)
LDCSI: 77.5 (69.7–85.3) (p = 0.049)
SDCSI: 85.6 ± 3.5 (78.7–92.5)
Packer et al., 1994 [23]Overall: 83 ± 6Overall: 85 ± 6Overall: 85 ± 6
SDCSI: 83 ± 6
LDCSI: 83 ± 20
Packer et al., 2006 [24]Overall: 81 ± 2.1
Regimen A: 82 ± 2.8
Regimen B: 80 ± 3.1
NROverall: 86 ± 1.9
Regimen A: 87 ± 2.6
Regimen B: 85 ± 2.8
Pezzotta et al., 1996 [25]Overall: 47.4
SR: 27.3
HR: 55.6
55.26NR
Rieken et al., 2011 [26]NRLPFS: 62
DPFS: 77
Overall: 73
Sirachainan et al., 2018 [28]NR41.8 ± 12.260 ± 11.2
Sung et al., 2013 [29]70 ± 10.3NR73.9 ±10.2
Tian et al., 2020 [30]NRNRPF: 50
TB: 58.3
Wahba et al., 2013. [31]79NR85
Yasuda et al., 2008 [32]82 (59–100)Patients ≤ 5 years: 75 (45–100)
Patients > 5 years: 88 (65–100)
Overall: 82 (59–100)
Patients ≤ 5 years: 75 (45–100)
Patients > 5 years: 88 (65–100)
6-year survival percentagesCarrie et al., 2009 [14]95 (62–87)7578 (66–90)
9-year survival percentagesPacker et al., 1994 [23]72 ± 13NRNR
10-year survival percentagesChristopherson et al., 2014 [15]677167
Gupta et al., 2022 [17]NR63.2 (52.1–74.4)74.1 (63.9–84.1)
Massimino et al., 2012 [21]42.6 ± 6NR46 ± 6
Rieken et al., 2011 [26]NRLPFS: 43
DPFS: 71
Overall: 53
Rutkowski et al., 2009 [27]NRHIT-SKK’87: 48.3 ± 9.3
HIT-SKK’92: 55.2 ± 9.2
HIT-SKK’87: 55.2 ± 9.3
HIT-SKK’92: 63.6 ± 7.6
Sirachainan et al., 2018 [28]NRNR48 ± 14

CI: confidence interval; DPFS: distal progression-free survival; EFS: event-free survival; HFRT: hyperfractionated radiation therapy; HIT-SKK’87 and ’92: (Brain Tumor Radiotherapy for Infants and Toddlers with Medulloblastoma) 1987 and 1992; HR: high risk; IFRT: involved field radiation therapy; LDCSI: low-dose craniospinal irradiation; LPFS: local progression-free survival; NR: not reported; OS: overall survival; PF: posterior fossa; PFRT: posterior fossa radiation therapy; PFS: progression-free survival; SD: standard deviation; SDCSI: standard-dose craniospinal irradiation; SR: standard risk; STRT: standard radiation therapy; TB: tumor bed. 95% CI noted in parenthesis and SD documented if reported.