Exploration of Medicine

From: Liquid biopsy for minimal residual disease and monitoring in early-stage non-small cell lung cancer: current clinical utility and implementation challenges

Table 4. Ongoing NSCLC MRD studies

Study name	Study design	Endpoint evaluated	Methodology used	LoD
MERMAID-1 [37]	Multi-center phase III	DFS of adjuvant ICI therapy	Signatera™	0.01% VAF
MERMAID-2 [38]	Multi-center phase III	DFS of Durvalumab therapy with/without MRD status	Signatera™	0.01% VAF
LC-SCRUM-Advantage/MRD [39]	Multi-center prospective observational	MRD stratification, therapy guidance	Tumor-informed sequencing	Variable
ALINA [40]	Multi-center phase III	Adjuvant ALK inhibitor therapy	NA	Not reported
NeoADAURA [41]	Multi-center phase III	Neoadjuvant osimertinib with or without chemotherapy versus chemotherapy alone prior to surgery	NA	Not reported
BR.31 [42]	Multi-center phase III	Adjuvant immunotherapy effectiveness	NGS	Not reported
ANVIL [43]	Multi-center phase III	Adjuvant immunotherapy effectiveness	NGS	Not reported

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ALK: anaplastic lymphoma kinase; DFS: disease-free survival; NA: information not available; VAF: variant allele frequency; NSCLC: non-small cell lung cancer

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