SE, ML, CCP, SB, VW, EM, RS, GB, & DJL contributed to study concept and manuscript preparation; SE, VW, EM, DJL contributed to data acquisition; SE, ML, SB, VW, EM, GB, DJL contributed to statistical analyses; DJL, GB—funding recipients; All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
This study was conducted consistent with the Declaration of Helsinki.
Consent to participate
Consent to publication
Availability of data and materials
The study was funded by New Jersey Health Foundation (ISFP 23-19); Osteopathic Heritage Foundation (2018002166). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Emrani S, Lamar M, Price CC, Wasserman V, Matusz E, Au R, et al. Alzheimer’s/vascular spectrum dementia: classification in addition to diagnosis. J Alzheimers Dis. 2020;73:63–71. [DOI] [PubMed]
Lamar M, Price CC, Giovannetti T, Swenson R, Libon DJ. The dysexecutive syndrome associated with ischaemic vascular disease and related subcortical neuropathology: a Boston process approach. Behav Neurol.2010;22:53–62. [DOI] [PubMed] [PMC]
Libon DJ, Lamar M, Price CC, Jefferson AL, Swenson R, Au R. Neuropsychological evaluation for vascular dementia. In: Smith GE, Farias ST, , editors. APA handbook of dementia. Washington: American Psychological Association; 2018. pp. 325–41.
Wong B, Lucente DE, MacLean J, Padmanabhan J, Quimby M, Brandt KD, et al. Diagnostic evaluation and monitoring of patients with posterior cortical atrophy. Neurodegener Dis Manag.2019;9:217–39. [DOI] [PubMed] [PMC]
Kamath V, Sutherland ER, and Chaney GA. A meta-analysis of neuropsychological functioning in the logopenic variant of primary progressive aphasia: comparison with the semantic and non-fluent variants. J Int Neuropsychol Soc.2020;26:322–30. [DOI] [PubMed]
Lamar M, Price CC, Davis KL, Kaplan E, Libon DJ. Capacity to maintain mental set in dementia. Neuropsychologia.2002;40:435–45. [DOI] [PubMed]
Fuster JM. The prefrontal cortex. 4th ed.London: Academic Press; 2008.
Fuster JM. Cortex and memory: emergence of a new paradigm. J Cogn Neurosci.2009;21:2047–72. [DOI] [PubMed]
Emrani S, Lamar M, Price CC, Wasserman V, Matusz E, Swenson R, et al. The thalamus and mental manipulation statistically-determined patients with mild cognitive impairment: a potential neurocognitive biomarker. Abstract presented at the 48th annual meeting of the International Neuropsychological Society;2020 Feb 5–8; Denver, USA. Salt Lake: International Neuropsychological Society; 2020.
Emrani S, Wasserman VJ, Baliga S, Matusz EF, Lamar M, Price C, et al. Working memory test performance in statistically-determined patients with mild cognitive impairment: an analysis of latency versus accuracy. Abstract presented at the 47th annual meeting of the International Neuropsychological Society;2019 Feb 20–23; New York, USA. Salt Lake: International Neuropsychological Society; 2019.
Lamar M, Price CC, Libon DJ, Penney DL, Kaplan E, Grossman M, et al. Alterations in working memory as a function of leukoaraiosis in dementia. Neuropsychologia.2007;45:245–54. [DOI] [PubMed] [PMC]
Lamar M, Catani M, Price CC, Heilman KM, Libon DJ. The impact of region-specific leukoaraiosis on working memory deficits in dementia. Neuropsychologia.2008;46:2597–601. [DOI] [PubMed]
Jak AJ, Bondi MW, Delano-Wood L, Wierenga C, Corey-Bloom J, Salmon DP, et al. Quantification of five neuropsychological approaches to defining mild cognitive impairment. Am J Geriatr Psychiatry.2009;17:368–75. [DOI] [PubMed] [PMC]
Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res.1982;17:37–49. [DOI] [PubMed]
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology.1994;44:2308–14. [DOI] [PubMed]
Edmonds EC, Ard MC, Edland SD, Galasko DR, Salmon DP, Bondi MW. Unmasking the benefits of donepezil via psychometrically precise identification of mild cognitive impairment: a secondary analysis of the ADCS vitamin E and donepezil in MCI study. Alzheimers Dement (N Y).2017;4:11–8. [DOI] [PubMed] [PMC]
Emrani S, Libon DJ, Lamar M, Price CC, Jefferson AL, Gifford KA, et al. Assessing working memory in mild cognitive impairment with serial order recall. J Alzheimers Dis.2018;61:917–28. [DOI] [PubMed] [PMC]
Bondi MW, Edmonds EC, Jak AJ, Clark LR, Delano-Wood L, McDonald CR, et al. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimers Dis.2014;42:275–89. [DOI] [PubMed] [PMC]
Thomas KR, Edmonds EC, Delano-Wood L, Bondi MW. Longitudinal trajectories of informant-reported daily functioning in empirically-defined subtypes of mild cognitive impairment. J Int Neuropsychol Soc.2017;23:521–7. [DOI] [PubMed] [PMC]
Eppig J, Wambach D, Nieves C, Price CC, Lamar M, Delano-Wood L, et al. Dysexecutive functioning in mild cognitive impairment: derailment in temporal gradients. J Int Neuropsychol Soc.2012;18:20–8. [DOI] [PubMed] [PMC]
Dixon WJ. Simplified estimation from censored normal samples. Ann Math Statist.1960;31:385–91.
Folstein MF, Folstein SE, McHugh PR. “Mini mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res.1975;12:189–98. [DOI] [PubMed]
Atkinson RC, Shiffrin RM. Human memory: a proposed system and its control processes. In: Spence KW, Spence JT, , editors. The psychology of learning and motivation: advances in research and theory. Vol. 2. New York: Academic Press; 1968. pp. 89–195.
Baddeley AD. Working Memory. Oxford: Clarendon Press; 1986. [DOI]
Norman DA. Toward a theory of memory and attention. Psychol Rev.1968;75:522–36. [DOI]
Norman DA, Shallice T. Attention to action. In: Davidson RJ, Schwartz GE, Shapiro DE, , editors. Consciousness and self-regulation. New York: Plenum; 1986. pp. 1–18.
Swartz BE, Halgren E, Fuster JM, Simpkins TF, Gee M, Mandelkern M. Cortical metabolic activation in humans during a visual memory task. Cerebral Cortex.1995;5:205–14. [DOI] [PubMed]
Buchsbaum BR, Olsen RK, Koch P, Berman KF. Human dorsal and ventral auditory streams subserve rehearsal-based and echoic processes during verbal working memory. Neuron.2005;48:687–97. [DOI] [PubMed]
Libert B, Wright EW, Jr, Gleason CA. Preparation- or intension-to-act, in relation to pre-event potentials recorded at the vertex. Electroencephalogr Clin Neurophysiol.1983;56:367–72. [DOI] [PubMed]
Abplanalp JM, Mirsky AF. Electroencephalographic correlates of delayed-alternation and visual discrimination learning in rhesus monkeys. J Comp Physiol Psychol.1973;85:123–31. [DOI] [PubMed]
Aron AR, Poldrack RA. The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biol Psychiatry.2005;57:1285–92. [DOI] [PubMed]
Sandson J, Albert ML. Varieties of perseveration. Neuropsychologia.1984;22:715–32. [DOI] [PubMed]
Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther.2014;6:37. [DOI] [PubMed] [PMC]
Heaton RK, Miller SW, Taylor MJ, Grant I. (2004). Revised comprehensive norms for an expanded Halstead-Reitan Battery: demographically adjusted neuropsychological norms for African American and Caucasian adults. Lutz (FL): Psychological Assessment Resources. https://www.parinc.com/products/pkey/357
Wechsler D. WAIS-III: administration and scoring manual: Wechsler adult intelligence scale. 3rd ed.San Antonio (TX): Psychological Corporation; 1997. [DOI]