Exploration of Medicine

Table 1. Comparison of experiment designs in the studies by Sanz-Ortega L et al. [38] and Nie W et al. [42]

Experiment parameter	Sanz-Ortega L et al. [38]	Nie W et al. [42]
MNP types	Single MNPs	MNCs built from 10 nm units
Size of MNPs	13 nm	Up to 100 nm
MNP-coating	APTES	PEI
EMF exposure time	90 minutes	24 hours
Method of OVA-peptide-specific CTL-activation	Conventional APCs	Biomimetic aAPC

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aAPC: artificial antigen-presenting cell; APTES: 3-aminopropyl-triethoxysilane; CTL: cytotoxic T-lymphocyte; EMF: external magnetic field; MNCs: magnetic nanoclusters; MNP: magnetic nanoparticle; OVA: ovalbumin; PEI: poly(ethylenimine)

Declarations

Acknowledgments

The authors thank Dr. A. Omelyanchik from Research and Educational Centre “Smart Materials and Biomedical Applications”, Immanuel Kant Baltic Federal University for editing the text and fruitful discussion.

Author contributions

IC: Conceptualization, Writing—original draft, Writing—review & editing. PF, IS, and SP: Writing—original draft, Writing—review & editing. KL: Conceptualization, Writing—review & editing. VA and MK: Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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