Summary statistics for clusters identified in population template using MIMneuro® voxel analysis. Parameters were a P-value of 1 minimum volume of 0 mL, and minimum z-score of 1.65
Statistic
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Cluster 5
Cluster 6
Cluster 7
Cluster 8
Cluster 9
Mean
1.90
1.87
−1.85
−1.66
−1.67
−1.67
−1.74
−1.71
1.66
Standard deviation
0.21
0.14
0.16
0.01
0.01
0.01
0.04
0.03
0.00
Median
1.84
1.85
−1.81
−1.66
−1.67
−1.67
−1.72
−1.71
1.66
Minimum
1.65
1.65
−2.22
−1.67
−1.68
−1.69
−1.78
−1.74
1.66
Maximum
2.65
2.19
−1.65
−1.65
−1.66
−1.65
−1.69
−1.67
1.66
Volume (mL)
11.53
2.62
1.67
0.10
0.08
0.05
0.04
0.02
0.02
P-value
0.93
0.99
0.99
1.00
1.00
1.00
1.00
1.00
1.00
Supplementary materials
The supplementary materials for this article are available at:
We would like to thank CereHealth Corp. for their donation of patient data and support of this study, and individuals Shane Quint, Laurie Haynie, Michaela Olson, Logan Langholz, and Christine Salva for their contributions to this work.
Author contributions
LMQ contributed to the conception and design of the study. CAR also contributed to its design. With some assistance from acknowledged individuals, LMQ processed all clinical and imaging data for the template and the cognitively impaired cohort. LMQ generated the template and performed all testing and statistical analysis. CAR performed all visual reads on the cognitively impaired cohort. LMQ wrote the first draft of the manuscript. CAR wrote sections of the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.
Conflicts of interest
Lindsay Quandt is an employee of CereHealth Corporation, the parent company of CereScan and CereMetrix Corporations. Cyrus Raji is an independent contractor for CereHealth Corporation.
Ethical approval
This study was approved by the IntegReview Institutional Review Board, Certificate CHDB112019.
Consent to participate
The informed consent to participate in the study was obtained from all participants.
Consent to publication
Not applicable.
Availability of data and materials
The datasets generated and analyzed for this manuscript are not publicly available because they are proprietary resources of CereHealth Corporation. Requests for access should be directed to Lindsay M. Quandt (LQuandt@ceremetrix.io).
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