Testing genetic association of TGFBR2 (rs6785358) gene polymorphism with CHD (n = 175, adjusted by sex)
Genotypic states
Genotype
Cases
Controls
OR (95% CI)
P-value
Codominant
A/A
31 (41.3%)
46 (46.0%)
1.00
0.0073*
A/G
30 (40%)
50 (50%)
1.13 (0.59–2.14)
G/G
14 (18.7%)
4 (4.0%)
0.20 (0.06–0.66)
Dominant
A/A
31 (41.3%)
46 (46.0%)
1.00
0.56
A/G + G/G
44 (58.7%)
54 (54.0%)
0.83 (0.46–1.53)
Recessive
A/A + A/G
61 (81.3%)
96 (96.0%)
1.00
0.0018*
G/G
14 (18.7%)
4 (4.0%)
0.19 (0.06–0.60)
Overdominant
A/A + G/G
45 (60%)
50 (50%)
1.00
0.19
A/G
30 (40%)
50 (50%)
1.49 (0.81–2.74)
*: P-value significant < 0.05
Declarations
Author contributions
ND: Formal analysis, Investigation, Writing—original draft. ESS and AAHE: Formal analysis, Investigation, Writing—original draft, Writing—review & editing. FRA, IE, and RE: Conceptualization, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
All authors declare that they have no conflicts of interest.
Ethical approval
The Ethical Committee at the Faculty of Medicine, Menoufia University approved the study (No. 11.2/2020 INTM2). The study is in accordance with the ethical standards of institutional research committee and with the 1964 Helsinki Declaration and its later amendments.
Consent to participate
An informed consent was obtained from the parents of all participating subjects of this study.
Consent to publication
Not applicable.
Availability of data and materials
The datasets that support the findings of this study are available from the corresponding author upon reasonable request.
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