Haematological cancer, effect of cannabinoids in animal models
Disease model
Treatment
Comparator
Results
Ref.
C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line
CBD (0, 12.5, or 25 mg/kg i.p.) single dose
Phosphate-buffered saline
Maximal apoptosis after 25 mg/kg; 12.5 mg/kg increased apoptosis but did not reach level of significance. CBD-induced apoptosis was mediated through CB2
C57BL/6 mice, i.p. injection of EL-4 cells, a murine lymphoma cell line
THC (0, 1, 3, or 5 mg/kg i.p.) single dose
Phosphate-buffered saline
THC caused a dose-dependent decrease in the viable tumour-cell number in the peritoneal cavity. With 5 mg/kg, a signif. proportion (77.3%) of the tumor cells showed apoptosis
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