Schematic description of the relationship between glutathione peroxidase 4 (GPX4) and isopentenyl-diphosphate (isopentenyl-PP) synthesis and metabolism. Farnesyl-PP: farnesyl-diphosphate; Geranyl-PP: geranyl-diphosphate; Geranylgeranyl-PP: geranylgeranyl-diphosphate; GSH: glutathione; GSSG: glutathione disulfide; HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme-A; Lipid-OH: lipid alcohol; Lipid-OOH: lipid peroxide; Se: selenium. Solid arrows indicate the sequence of the enzymatic reactions whereas dashed arrows indicate the final biological event