NET formation. Neutrophils employ two primary strategies to combat microbes: phagocytosis and releasing NETs depending on their stimuli. (a) Suicidal/classical NETosis with escaping mechanism of invasive S. pneumoniae that expressed virulent factor; (b) vital NETosis. NET: neutrophil extracellular trap. Created in BioRender. Yusoff, M. (2023) BioRender.com/n72w387