From:  Functional lignin hydrogels for biosensors and biomedical therapy

 Lignin based hydrogels in strain sensor applications.

Hydrogel compositionLignin kindSynthesisPropertiesApplicationsReferences
Polyvinyl alcohol (PVA), carboxymethyl chitosan (CMC), cellulose nanofibrils (CNF), lignin-based carbon (LC) nanoparticlesLignin-derived carbon (LC)Dispersed lignin-based carbon (LC) was combined with PVA, CMC, and CNF that had been dissolved in water. Several freeze-thaw cycles were used to the mixture in order to create a physically crosslinked conductive hydrogel (PSH)Tensile strength: 133 kPa, compression stress: 37.7 kPa, excellent stretchability and fatigue resistanceMonitoring palm clutching, finger bending, elbow flexion, wearable flexible strain sensors[73]
Enzymatic hydrolysis lignin (DEL), poly (vinyl alcohol) (PVA), silver nanoparticles (AgNP)Enzymatic hydrolysis lignin (DEL)In situ reduction of Ag+ with sodium citrate in DEL-PVA matrix; promotes nanophase separation and AgNP formationStrain at break: 1,220%, tensile strength: 13.3 MPa, toughness: 78.1 MJ/m3, electrical conductivity: ~1.0 S/mFlexible and wearable strain sensors, motion-responsive electronic devices[74]
Sulfonated lignin-coated silica nanoparticles (LSNs), polyacrylamide (PAM), ferric ions (Fe3+)Sulfonated ligninRapid gelation in ~60 seconds via self-catalytic redox reaction between Fe3+ and catechol groups on LSNsElongation: ~1,100%, tensile strength: ~180 kPa, compressive strength: ~480 kPa, hysteresis ratio: < 15%Strain sensors for wearable electronics, human motion tracking[75]
Lignin-graft-poly(acrylic acid) (LPAA), acrylamide (AM), sodium chloride (NaCl)Lignin-graft-poly (acrylic acid) (LPAA)By adding LPAA to an AM/NaCl solution, composite conductive hydrogels were created, creating a hydrogen-bonded crosslinked network without the need for outside stimuliExcellent UV shielding: 99.95%, good transparency, strain sensing: gauge factor = 2.51 (100–500% strain range), tensile strength: 96 kPa, compressive strength: 0.54 MPaWearable strain sensors for physical activity monitoring, flexible and transparent electronics, UV-protective wearable devices[76]
Gelatin, polypyrrole, sodium lignosulfonateSodium lignosulfonateSimple fabrication via dynamic noncovalent interactionsBiocompatibility, conductivity, high strain sensitivity: GF = 6.08, fast response: 107 milliseconds, strong adhesion: 23.88 kPa to pig skinWearable flexible strain sensors, real-time monitoring of human physiological activities[77]
Lignin–Fe3+ self-catalytic system, 2-hydroxyethyl acrylate (HE-AA), [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), water–ethylene glycol (EG) mixtureLignin–Fe3+Rapid redox polymerization of lignin–Fe3+ with HE-AA and DMAPS in EG solutionFracture stress: 236.15 kPa, elongation at break: 556.8%, self-adhesion: ~110 ± 3.1 kPa on paper, water retention: 73.7% (non-drying), antifreezing: stable from −60°C to 60°C, sensor performance-gauge factor: 6.044, response time: 198 msStrain sensors for skin-mounted flexible electronics, wearable health monitoring and motion tracking[78]
Poly (acrylic acid) (PAA), liquid metal (LM), TEMPO-oxidized ligninTEMPO-oxidized ligninThe hydrogel was created by polymerizing acrylic acid with free radicals at room temperature. TEMPO-oxidized lignin was used to stabilize the liquid metal and start the gel formation processHigh conductivity, self-healing, strong adhesion, high tensile strength, antibacterial activity (due to lignin), strain sensing accuracy, stable electrical outputFlexible and wearable sensors, electronic skin (e-skin), health monitoring devices, soft robotics[79]
Lignosulfonate (LS), ferric ions (Fe), nanocelluloseLignosulfonate (LS)By combining lignosulfonate, Fe2+ ions, and nanocellulose, the hydrogel was quickly created at ambient temperature in 63 seconds without the requirement for UV light or additional heatingRapid gelation (as fast as 63 seconds with 8 wt% LS), high tensile strength: 227 kPa, excellent elongation at break: 515%, self-supporting and flexible structureWearable strain sensors for monitoring human joint movement, flexible electronics, potential for biomedical and motion detection devices[80]
Sulfonated lignin–silica nanoparticles (LSNs), iron ions (Fe3+), polyacrylamide (PAM), MXene (Ti3C2Tx)Sulfonated ligninSNs, Fe3+, and MXene were combined at room temperature to synthesize the hydrogel.Tensile strength: ~76 kPa, elongation at break: ~700%, self-adhesion: ~19.9 kPaFlexible and wearable strain sensor electronics, human motion sensing and health monitoring[81]