Results of monitoring the condition of volunteer HA (22 years old) with an established positive reaction to the H. pylori test, with a violation of the treatment protocol.
Description of the volunteers’ condition at the time of testing
Comparison of signal fingerprints at zero load level (pink) and after 10 min (blue)
Comparison of signal fingerprints at zero load level (pink) and after 30 min (blue)
Final conclusion on the sensory assessment of H. pylori, taking into account the accepted hypothesis
HA1.0, H. pylori test not performed, nausea, 16/03/2022
The test is positive (+), without inflammation of the esophagus.I went to see a doctor and was prescribed therapy.
d, %
11 (–)
23 (++)
HA1.1, H. pylori test positive, condition improved, 18/03/2022, 3 days of therapy
The test is positive (+), without inflammation of the esophagus, the titer has not changed.
d, %
4 (–)
34 (++)
HA1.2, improvement of condition, 21/03/2022, 6 days of therapy
The relative difference in the area of the figures, d, %, correlates with the classification of the degrees of contamination of the mucous membrane of Helicobacter pylori (H. pylori) based on the number of microbial bodies in the field of view: lack of activity (–); the average (++) is up to 40 microbial bodies; high (+++) is more than 40 microbial bodies.
Declarations
Acknowledgements
The authors thank the volunteers and clinical partners involved in the study for their participation and support.
Author contributions
TAK: Conceptualization, Supervision, Project administration, Writing—review & editing. DM: Methodology, Software, Formal analysis, Investigation, Writing—original draft, Writing—review & editing. RU: Methodology, Software, Validation, Formal analysis, Investigation, Visualization, Writing—review & editing. AK: Resources, Data curation, Writing—review & editing. All authors read and approved the final manuscript.
Conflicts of interest
The authors declare that they have no competing interests.
Ethical approval
This study involving human participants was conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. The study was approved by the Ethics Committee of Voronezh State Medical University named after N.N. Burdenko, approval number VSMU-2020-07.
Consent to participate
Written informed consent was obtained from all individual participants included in the study.
Consent to publication
Not applicable.
Availability of data and materials
The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Funding
This research was supported by internal grants of the Institute, and no external funding was received. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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