Biomarkers—quantitative and objective indicators of disease presence, severity, therapeutic efficacy/toxicity, and patient stratification in clinical trials—are central to diagnostic development.
The authors thank the volunteers and clinical partners involved in the study for their participation and support.
Author contributions
TAK: Conceptualization, Supervision, Project administration, Writing—review & editing. DM: Methodology, Software, Formal analysis, Investigation, Writing—original draft, Writing—review & editing. RU: Methodology, Software, Validation, Formal analysis, Investigation, Visualization, Writing—review & editing. AK: Resources, Data curation, Writing—review & editing. All authors read and approved the final manuscript.
Conflicts of interest
The authors declare that they have no competing interests.
Ethical approval
This study involving human participants was conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. The study was approved by the Ethics Committee of Voronezh State Medical University named after N.N. Burdenko, approval number VSMU-2020-07.
Consent to participate
Written informed consent was obtained from all individual participants included in the study.
Consent to publication
Not applicable.
Availability of data and materials
The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Funding
This research was supported by internal grants of the Institute, and no external funding was received. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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