Plasma membrane transporters and channels involved in hepatobiliary function

Cells Membrane Protein Gene Substrates
Hepatocytes Basolateral NTCP SLC10A1 Bile acids
OATP1B1 SLCO1B1 Bile acids, organic anions
OATP1B3 SLCO1B3 Bile acids, organic anions
MRP3 ABCC3 Bile acids, organic anions
MRP4 ABCC4 Bile acids, organic anions
NBC4 SLC4A5 Na+/HCO3symporter
NHE1 SLC9A1 Na+/H+ antiporter
SK2 KCNN2 K+ channel
BSC SLC12A2 Na+/Cl symporter
AQP9 AQP9 Water channel
Hepatocytes Canalicular BSEP ABCB11 Bile acids
MRP2 ABCC2 Organic anions
MDR1 ABCB1 Several
BCRP ABCG2 Bile acids, steroids
MDR3 ABCB4 Phosphatidyl choline
FIC1 ATP8B1 Phosphatidyl serine
ABCG5/G8 ABCG5/G8 Cholesterol
NHE3 SLC9A3 Na+/H+ antiporter
AQP8 AQP8 Water channel
Cholangiocytes Basolateral OSTα/β SLC51A/B Bile acids, organic anions
NHE1 SLC9A1 Na+/H+ antiporter
NDCBE SLC4A8 Cl/HCO3 antiporter
SK2 KCNN2 K+ channel
BSC SLC12A2 Na+/Cl symporter
MRP3 ABCC3 Bile acids, organic anions
MRP4 ABCC4 Bile acids, organic anions
AQP4 AQP4 Water channel
Cholangiocytes Apical ASBT SLC10A2 Bile acids
AE2 SLC4A2 Cl/HCO3 antiporter
CFTR ABCC7 Cl channel
NBC4 SLC4A5 Na+/HCO3 symporter
AQP1 AQP1 Water channel

BCRP: breast cancer resistance protein; HCO3: bicarbonate; KCNN2: potassium calcium-activated channel subfamily N member 2