Area under the curve, sensitivity, specificity, and likelihood ratio of ZO-1 and cystatin C
Parameter
Cut off value
AUC(95% confidence interval)
Sensitivity(95% confidence interval)
Specificity(95% confidence interval)
p-value
ZO-1
> 3.412 ng/mL
0.998 (0.995–1.000)
97.22% (87.12–99.87)
97.50% (87.12–99.87)
< 0.0001
Cystatin C
> 1.958 mg/L
0.978 (0.949–1.000)
91.67% (80.14–97.42)
97.50% (87.12–99.87)
< 0.0001
AUC: area under the curve; ZO-1: zonula occludens-1
Declarations
Author contributions
BV: Conceptualization, Resources, Supervision, Formal analysis, Validation, Writing—original draft, Writing—review & editing. RK: Methodology, Data curation, Formal analysis. MW: Investigation, Supervision. All authors read and approved the final manuscript.
Conflicts of interest
The authors declare that there are no conflicts of interest.
Ethical approval
This study was reviewed and approved by the JIPMER scientific advisory committee and Institute Ethics Committee for human studies [JIP/IEC/2019/499].
Consent to participate
All patients were provided with informed written consent regarding the data collection and scientific publication.
Consent to publication
Not applicable.
Availability of data and materials
The raw data underlying this article will be shared on reasonable request to the corresponding author.
Funding
This work was supported by the JIPMER intramural research grant [Phase-I/2020-2021/MSc/23]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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