Biological functions of caspase-2 substrates. GO enrichment analysis of significantly enriched biological processes within proteins described as caspase-2 substrates (compiled by MEROPS database)

GO biological process complete FE FDR
Female meiosis chromosome segregation 42.02 1.40 × 10–2
Positive regulation of chromosome segregation 16.16 4.11 × 10–3
Phosphatidylinositol-3-phosphate biosynthetic process 16.01 1.93 × 10–2
Negative regulation of mRNA splicing, via spliceosome 16.01 1.92 × 10–2
Cellular response to misfolded protein 15.28 2.12 × 10–2
Protein quality control for misfolded or incompletely synthesized proteins 12.45 3.58 × 10–2
Regulation of heterochromatin assembly 12.01 3.98 × 10–2
Regulation of androgen receptor signaling pathway 12.01 3.96 × 10–2
Positive regulation of chromosome separation 11.59 4.34 × 10–2
Establishment of spindle orientation 10.77 1.66 × 10–2
Regulation of mitotic sister chromatid segregation 10.70 1.44 × 10–3
mRNA splicing, via spliceosome 8.79 5.12 × 10–12
Histone deacetylation 8.69 1.22 × 10–2
Neuron apoptotic process 7.64 5.00 × 10–2
Regulation of mitotic metaphase/anaphase transition 7.39 3.29 × 10–3
Positive regulation of chromosome organization 7.20 1.45 × 10–3
Positive regulation of DNA recombination 7.10 2.60 × 10–2
Regulation of translational initiation 6.15 4.46 × 10–2
Positive regulation of translation 5.92 2.16 × 10–3
Positive regulation of apoptotic signaling pathway 5.86 5.34 × 10–3
Nuclear export 5.82 5.50 × 10–3
Ribonucleoprotein complex assembly 5.81 2.02 × 10–4
Regulation of mRNA stability 5.57 6.23 × 10–4
Negative regulation of translation 5.03 6.51 × 10–3
Positive regulation of proteasomal protein catabolic process 5.03 4.86 × 10–2
mRNA transport 4.84 3.01 × 10–2
Positive regulation of response to DNA damage stimulus 4.61 2.06 × 10–2
Mitotic nuclear division 4.48 2.43 × 10–2
Positive regulation of leukocyte differentiation 4.30 3.02 × 10–2
Negative regulation of organelle organization 4.18 2.90 × 10–4
Chromatin remodeling 3.97 5.46 × 10–3
Negative regulation of catabolic process 3.36 1.92 × 10–2
Translation 3.34 8.75 × 10–3
Ubiquitin-dependent protein catabolic process 2.97 3.21 × 10–3
Cell division 2.81 1.75 × 10–2
DNA repair 2.74 2.96 × 10–2
ncRNA metabolic process 2.73 2.24 × 10–2
Regulation of plasma membrane bounded cell projection organization 2.70 1.00 × 10–2
Intracellular signal transduction 2.17 1.57 × 10–3
Cellular protein localization 2.06 1.40 × 10–2
Protein transport 2.03 3.42 × 10–2

The most specific GO term is shown (hierarchically sorted terms). Fold enrichment (FE) ≥ 2 and Fisher’s exact test with false discovery rate (FDR) less than 0.05 as calculated by the Benjamini-Hochberg procedure were used as thresholds in the enrichment analysis. ncRNA: noncoding RNA