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References
Nugrahapraja H, Sugiyo PWW, Putri BQ, Ni’matuzahroh N, Fatimah F, Huang L, et al. Effects of Microplastic on Human Gut Microbiome: Detection of Plastic-Degrading Genes in Human Gut Exposed to Microplastics—Preliminary Study.Environments. 2022;9:140. [DOI]
Sun A, Wang WX. Human Exposure to Microplastics and Its Associated Health Risks.Environ Health (Wash). 2023;1:139–49. [DOI] [PubMed] [PMC]
Bhattacharyya S, Greer ML, Salehi M. Impact of micro- and nanoplastics exposure on human health: focus on neurological effects from ingestion.Front Public Health. 2025;13:1681776. [DOI] [PubMed] [PMC]
Tamargo A, Molinero N, Reinosa JJ, Alcolea-Rodriguez V, Portela R, Bañares MA, et al. PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion.Sci Rep. 2022;12:528. [DOI] [PubMed] [PMC]
Chang X, Xue Y, Li J, Zou L, Tang M. Potential health impact of environmental micro‐ and nanoplastics pollution.J Appl Toxicol. 2019;40:4–15. [DOI] [PubMed]
Haldar S, Yhome N, Muralidaran Y, Rajagopal S, Mishra P. Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review.Genes. 2023;14:590. [DOI] [PubMed] [PMC]
Tang KHD. Toxic Effects of Nanoplastics on Animals: Comparative Insights into Microplastic Toxicity.Environments. 2025;12:429. [DOI]
Jeong A, Park SJ, Lee EJ, Kim KW. Nanoplastics exacerbate Parkinson’s disease symptoms in C. elegans and human cells.J Hazard Mater. 2024;465:133289. [DOI] [PubMed]
Gao B, Shi X, Zhao M, Ren F, Xu W, Gao N, et al. Mixture Effects of Polystyrene Microplastics on the Gut Microbiota in C57BL/6 Mice.ACS Omega. 2025;10:7597–608. [DOI] [PubMed] [PMC]
Yang XY, Zhang ZW, Chen GD, Yuan S. Gut microbiome remodeling induced by microplastic exposure in humans.Gut Microbes. 2026;18:2617696. [DOI] [PubMed] [PMC]
Zhang X, Wang H, Peng S, Kang J, Xie Z, Tang R, et al. Effect of microplastics on nasal and intestinal microbiota of the high-exposure population.Front Public Health. 2022;10:1005535. [DOI] [PubMed] [PMC]
Lv J, Liu G, Wang Z, Zhang J, Li Y, Wang Y, et al. Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte.J Nanobiotechnology. 2025;23:537. [DOI] [PubMed] [PMC]
Fu X, Liu L, Han H, Li Y, Si S, Xu B, et al. Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice.Environ Toxicol. 2023;38:1277–91. [DOI] [PubMed]
Jiang J, Shu Z, Qiu L. Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier.Environ Geochem Health. 2024;46:238. [DOI] [PubMed]
Sofield CE, Anderton RS, Gorecki AM. Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences.Curr Issues Mol Biol. 2024;46:4186–202. [DOI] [PubMed] [PMC]
Fackelmann G, Pham CK, Rodríguez Y, Mallory ML, Provencher JF, Baak JE, et al. Current levels of microplastic pollution impact wild seabird gut microbiomes.Nat Ecol Evol. 2023;7:698–706. [DOI] [PubMed] [PMC]
Zhao B, Zhang C, Wang C, Zhao HM. Micro/Nanoplastics Alter Daphnia magna Life History by Disrupting Glucose Metabolism and Intestinal Structure.Sustainability. 2025;17:10728. [DOI]
Chuang HH, Lee LA, Chuang LP, Li HY, Huang YS, Chou SH, et al. Alterations of Gut Microbiome Composition and Function Pre- and Post-Adenotonsillectomy in Children with Obstructive Sleep Apnea.J Otolaryngol Head Neck Surg. 2024;53:19160216241293070. [DOI] [PubMed] [PMC]
Qiao J, Chen R, Wang M, Bai R, Cui X, Liu Y, et al. Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction.Nanoscale. 2021;13:8806–16. [DOI] [PubMed]
Tafesh-Edwards G, Eleftherianos I. The role of Drosophila microbiota in gut homeostasis and immunity.Gut Microbes. 2023;15:2208503. [DOI] [PubMed] [PMC]
Yin L, Yang M, Teng A, Ni C, Wang P, Tang S. Unraveling Microplastic Effects on Gut Microbiota across Various Animals Using Machine Learning.ACS Nano. 2024;19:369–80. [DOI] [PubMed]
Jiang Z, Mei L, Li Y, Guo Y, Yang B, Huang Z, et al. Enzymatic Regulation of the Gut Microbiota: Mechanisms and Implications for Host Health.Biomolecules. 2024;14:1638. [DOI] [PubMed] [PMC]
Mithieux G. Gut Microbiota and Host Metabolism: What Relationship.Neuroendocrinology. 2017;106:352–6. [DOI] [PubMed]
Nunna Sai Venkata L, Mishra AK, Mohanta YK, Rustagi S, Bahuguna A, Tomar A, et al. The Gut Gambit: A Review of How Microbial Imbalance Fuels Metabolic Mayhem.Nutrients. 2026;18:888. [DOI] [PubMed] [PMC]
Niu H, Liu S, Jiang Y, Hu Y, Li Y, He L, et al. Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota.Metabolites. 2023;13:739. [DOI] [PubMed] [PMC]
He J, Tang Q, Liu YC, Wang LJ, Chai YF. Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome.Antioxidants. 2025;14:721. [DOI] [PubMed] [PMC]
Shen Y, Fan N, Ma SX, Cheng X, Yang X, Wang G. Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy.MedComm. 2025;6:e70168. [DOI] [PubMed] [PMC]
Chae YR, Lee YR, Kim YS, Park HY. Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome.J Microbiol Biotechnol. 2024;34:747–56. [DOI] [PubMed] [PMC]
Amabebe E, Robert FO, Agbalalah T, Orubu ESF. Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.Br J Nutr. 2020;123:1127–37. [DOI] [PubMed]
Chiang CC, Yeh H, Shiu RF, Chin WC, Yen TH. Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions.World J Gastroenterol. 2024;30:1011–7. [DOI] [PubMed] [PMC]
Yilmaz Y, Simsek C, Ucdal M, Kaya E. Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction.Hepatol Forum. 2025;6:199–206. [DOI] [PubMed] [PMC]
Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis.Cell Mol Life Sci. 2017;74:2959–77. [DOI] [PubMed] [PMC]
Chi L, Tu P, Ru H, Lu K. Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms.Gut Microbes. 2021;13:1921912. [DOI] [PubMed] [PMC]
Jena R, Singh NA, Ahmed N, Choudhury PK. Bifidobacteria in antibiotic-associated dysbiosis: restoring balance in the gut microbiome.World J Microbiol Biotechnol. 2025;41:297. [DOI] [PubMed]
Bozkurt HS, Yörüklü HC, Bozkurt K, Denktaş C, Bozdoğan A, Özdemir O, et al. Biodegradation of microplastic by probiotic bifidobacterium.Int J Glob Warm. 2022;26:429–43. [DOI]
Venkidesh BS, Shankar SR, Narasimhamurthy RK, Rao SBS, Mumbrekar KD. Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study.Clin Transl Oncol. 2023;25:3165–73. [DOI] [PubMed] [PMC]
Bazeli J, Banikazemi Z, Hamblin MR, Sharafati Chaleshtori R. Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?Front Nutr. 2023;10:1186724. [DOI] [PubMed] [PMC]
El-Kurdi N, El-Shatoury S, ElBaghdady K, Hammad S, Ghazy M. Biodegradation of polystyrene nanoplastics by Achromobacter xylosoxidans M9 offers a mealworm gut-derived solution for plastic pollution.Arch Microbiol. 2024;206:238. [DOI] [PubMed] [PMC]
Peng BY, Xu Y, Zhou X, Wu WM, Zhang Y. Generation and Fate of Nanoplastics in the Intestine of Plastic-Degrading Insect (Tenebrio molitor Larvae) during Polystyrene Microplastic Biodegradation.Environ Sci Technol. 2024;58:10368–77. [DOI] [PubMed]
Li Y. Legislation and Policy on Pollution Prevention and the Control of Marine Microplastics.Water. 2022;14:2790. [DOI]
McIlwraith HK, Kim J, Helm P, Bhavsar SP, Metzger JS, Rochman CM. Evidence of Microplastic Translocation in Wild-Caught Fish and Implications for Microplastic Accumulation Dynamics in Food Webs.Environ Sci Technol. 2021;55:12372–82. [DOI] [PubMed]
Mittal N, Tiwari N, Singh D, Tripathi P, Sharma S. Toxicological impacts of microplastics on human health: a bibliometric analysis.Environ Sci Pollut Res. 2023;31:57417–29. [DOI] [PubMed]
Blackburn K, Green D. The potential effects of microplastics on human health: What is known and what is unknown.Ambio. 2021;51:518–30. [DOI] [PubMed] [PMC]
Nafea TH, Chan FKS, Xu H, Wang C, Xiao H, He J. Status of management and mitigation of microplastic pollution.Crit Rev Environ Sci Technol. 2024;54:1734–56. [DOI]
Prasittisopin L. Unveiling the duality of cement and concrete addressing microplastic pollution: a review.Environ Sci Pollut Res. 2025;32:8717–42. [DOI] [PubMed]
Chaukura N, Kefeni KK, Chikurunhe I, Nyambiya I, Gwenzi W, Moyo W, et al. Microplastics in the Aquatic Environment—The Occurrence, Sources, Ecological Impacts, Fate, and Remediation Challenges.Pollutants. 2021;1:95–118. [DOI]
Chartres N, Cooper CB, Bland G, Pelch KE, Gandhi SA, BakenRa A, et al. Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review.Environ Sci Technol. 2024;58:22843–64. [DOI] [PubMed] [PMC]
Gecegelen E, Ucdal M, Dogu BB. A novel risk factor for dementia: chronic microplastic exposure.Front Neurol. 2025;16:1581109. [DOI] [PubMed] [PMC]
Arneson D, Shu L, Tsai B, Barrere-Cain R, Sun C, Yang X. Multidimensional Integrative Genomics Approaches to Dissecting Cardiovascular Disease.Front Cardiovasc Med. 2017;4:8. [DOI] [PubMed] [PMC]
Guillotin S, Delcourt N. Marine Neurotoxins’ Effects on Environmental and Human Health: An OMICS Overview.Mar Drugs. 2021;20:18. [DOI] [PubMed] [PMC]
Singh P, Dhir YW, Gupta S, Kaushal A, Kala D, Nagraiik R, et al. Relevance of proteomics and metabolomics approaches to overview the tumorigenesis and better management of cancer.3 Biotech. 2025;15:58. [DOI] [PubMed] [PMC]
Gao C, Shen X, Tan Y, Chen S. Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s disease.J Neuroinflammation. 2022;19:215. [DOI] [PubMed] [PMC]
