From:  Non-HDL to HDL cholesterol ratio as a biomarker associated with decompensation in chronic liver disease

 Classification performance of base and combined models for identifying decompensated vs. compensated patients by NHHR tertiles.

GroupModelAUC (95% CI)ΔAUC vs. BaseP (DeLong)NRIIDI
Overall cohort (n = 220)Base Model0.73 (0.67–0.79)----
Base + NHHR0.79 (0.73–0.85)+ 0.06< 0.0010.200.041
NHHR tertile 1 (≤ 2.0) (n = 74)Base Model0.70 (0.58–0.82)----
Base + NHHR0.74 (0.62–0.85)+ 0.040.1380.080.010
NHHR tertile 2 (2.1–3.0) (n = 73)Base Model0.74 (0.63–0.85)----
Base + NHHR0.78 (0.68–0.88)+ 0.040.0450.170.026
NHHR tertile 3 (> 3.0) (n = 73)Base Model0.75 (0.65–0.85)----
Base + NHHR0.81 (0.72–0.89)+ 0.06< 0.0010.270.053

Base Model comprised age, sex, and MELD-3.0 score. AUC: area under the receiver operating characteristic curve; CI: confidence interval; NRI: net reclassification improvement; IDI: integrated discrimination improvement; MELD: Model for End-Stage Liver Disease; NHHR: non-high-density lipoprotein/high-density lipoprotein cholesterol ratio.