From:  Non-HDL to HDL cholesterol ratio as a biomarker associated with decompensation in chronic liver disease

 Baseline characteristics of study participants stratified by NHHR tertiles (n = 220).

CharacteristicTertile 1 (NHHR ≤ 2.0) (n = 74)Tertile 2 (NHHR 2.1–3.0) (n = 73)Tertile 3 (NHHR > 3.0) (n = 73)P value
NHHR, mean ± SD1.79 ± 0.132.57 ± 0.273.80 ± 0.35< 0.001
Age, years, mean ± SD52.0 ± 10.555.1 ± 12.356.4 ± 11.70.178
Male sex, n (%)48 (65)42 (58)48 (66)0.423
HDL-C, mg/dL, mean ± SD47.2 ± 10.138.7 ± 8.831.5 ± 7.1< 0.001
Non-HDL-C, mg/dL, mean ± SD111.0 ± 16.0123.6 ± 18.7138.2 ± 19.8< 0.001
MELD-3.0 score, mean ± SD12.3 ± 4.213.1 ± 4.515.0 ± 5.10.028
Serum albumin, g/dL, mean ± SD3.4 ± 0.73.1 ± 0.82.7 ± 0.8< 0.001
Total bilirubin, mg/dL, mean ± SD2.3 ± 1.72.8 ± 2.03.1 ± 2.10.092
INR, mean ± SD1.42 ± 0.311.45 ± 0.341.50 ± 0.380.166
Platelet count, × 109/L, mean ± SD155 ± 60148 ± 58142 ± 550.212
Etiology of CLD, n (%)0.357
    Alcohol-related33 (45)35 (48)38 (52)
    Metabolic (MASLD)21 (28)19 (26)16 (22)
    Viral (HBV/HCV)16 (22)15 (21)15 (21)
    Other*4 (5)4 (5)4 (5)
Child-Pugh class (A/B/C), n40/26/834/28/1130/32/110.052
Decompensated disease, n (%)23 (31.1)34 (46.6)39 (53.4)< 0.001

*: Includes autoimmune, Wilson’s disease, cryptogenic, and other less common etiologies. CLD: chronic liver disease; HDL-C: high-density lipoprotein cholesterol; INR: international normalized ratio; MASLD: metabolic dysfunction-associated steatotic liver disease; MELD: Model for End-Stage Liver Disease; NHHR: non-high-density lipoprotein/HDL-C ratio; SD: standard deviation.