Summary of diagnostic evaluations, results, and interpretations.
Test
Result
Normal/reference
Interpretation
EGD
LA Grade B reflux esophagitis; no bleeding.
N/A
Endoscopic evidence of esophagitis
Esophageal biopsy (HSV features)
Morphologic features of herpesvirus infection on hematoxylin and eosin staining (multinucleation, nuclear molding, and intranuclear inclusions); HSV immunohistochemistry and polymerase chain reaction were not performed.
The abstract was originally presented at the American College of Gastroenterology Conference 2025 in Phoenix, Arizona https://journals.lww.com/ajg/fulltext/2025/10002/s4309_intersecting_pathologies__herpes_simplex.4308.aspx. The abstract, on conference acceptance, was published in the American Journal of Gastroenterology. However, the abstract has since been modified to fit the requirements of this journal. The publication of this manuscript and the data involved in other journals is not affected by the conference organizers.
Author contributions
SS: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Visualization. BY: Writing—original draft. DS: Writing—review & editing. SCS: Writing—review & editing. TO: Supervision, Validation, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
There is a familial relation between the authors Sahil Sabharwal, Deepak Sabharwal, and Sarat C. Sabharwal. The authors declare that this relationship did not influence the work, and there are no conflicts of interest. The other authors declare that there are no conflicts of interest.
Ethical approval
This case report was conducted in accordance with the World Medical Association Declaration of Helsinki. Institutional Review Board approval from the University of Arkansas for Medical Sciences was not required for the publication of a single de-identified case report in accordance with institutional policy.
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent to publication
Informed consent to publication was obtained from the relevant participant, including consent for publication of any accompanying images.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on a reasonable request.
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