Recent miRNA-related studies in AIS

miR-20a-3p2022Identify the neuroprotective effect of miR-20a-3p based on the astrocytes[82]
miR-126a-5p2021miR-126a-5p is a novel potential target for ischemic stroke therapy due to its protection against cerebral I/R injury via directly targeting nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)[83]
miR-1902021miR-190 confers protection against brain I/R injury by modulating Rho/Rho-kinase signaling[84]
miR-30c2020miR-30c can improve the pathological damage of rats with I/R injury and plays a neuroprotective role both in vivo and in vitro by targeting SRY-box transcription factor 9 (SOX9)[85]
miR-222020miR-22 exerts its neuroprotective and angiogenic functions via the PI3K/Akt signaling pathway, at least partly, in rats under cerebral ischemia-reperfusion[86]
miR-12022020miR-1202 exerts a neuroprotective effect by negatively regulating its target protein Rab1a, which can inactivate TLR4/NF-κB-involved inflammatory signaling pathway in OGD/reoxygenation (R) induced human microglia (HM) cells[87]
miR-532-5p2020These findings reveal that miR-532-5p protects against ischemic stroke by inhibiting phosphatase and tensin homolog (PTEN) and activating the PI3K/Akt signaling pathway stroke[88]
miR-18b2020These data indicate that miR-18b protects against cerebral I/R injury by inhibiting annexin A3 (ANXA3) and activating PI3K/Akt pathway[89]
miR-219a-5p2020Upregulation of miR-219a-5p decreases cerebral I/R injury by targeting phosphodiesterase 4D (Pde4d) in vitro[90]
miR-193b-3p2020miR-193b-3p has a potentially neuroprotective effect on focal cerebral I/R injury by inhibiting 5-lipoxygenase (5-LOX) expression[91]