Table Info

Table 2.

Adverse events according to group

Adverse event	Memantine (n = 17)	Sodium valproate (n = 16)	Clinical severity CTCAE
Any adverse event	8	7	Grade 1 mild
Somnolence	4	6	Grade 1 mild
Poor concentration	2	0	Grade 1 mild
Parasomnia	0	1	Grade 1 mild
Dizziness	2	0	Grade 1 mild

CTCAE: common terminology criteria for adverse event (from US Department of Health and human services)

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/100442_sup_1.pdf.

Declarations

Acknowledgments

Thanks are due to Torrent Pharmaceuticals, Mexico for providing both memantine and valproate for this study.

Author contributions

DVG: Conceptualization, Resources, Data curation, Writing—original draft, Writing—review & editing. IRL: Conceptualization, Writing—review & editing. AON: Investigation, Writing—review & editing. FRR: Resources. HGHR and JMSM: Formal analysis. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The protocol study was approved by the Research and Ethics committees of Hospital Central (no. 74-19). It was also registered in the National Institutes of Health Clinical Trials of the United States (registration NCT04698525 for clinical trials) and complied with the Declaration of Helsinki and its later amendments.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The datasets for this study can be found in the Clinical Trials of the National Institutes of Health of the United States (https://clinicaltrials.gov/ct2/results?pg=1&load=cart&id=NCT04698525).

Funding

Not applicable.

Copyright

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